Letter to the Editor Letters to the Editor will be published, if suitable, as space permits. They should not exceed 1000 words (typed double-spaced) in length and may be subject to editing or abridgment. Nevertheless, both our study and the study conducted by Response by Liu and Hu to Letter Regarding Delaney et al demonstrate that low dose agonists (thrombin, Article, “Class III PI3K Positively Regulates 0.018 U/mL and 0.025 U/mL; collagen, 0.5 μg/mL; or CRP, 0.5 Platelet Activation and Thrombosis via PI(3) μg/mL) still activate significant ROS generation in platelets de- P-Directed Function of NADPH Oxidase” ficiency of NOX1, NOX2, or VPS34, suggesting the existence of In Response: other mechanisms of ROS generation independent of these pro- We welcome the letter commenting on our recent study, 7,8 teins. The NOX family consists of 7 catalytic homologues, in which raised a question on whether the defective reactive oxygen addition to NOX1 and NOX2, NOX4 is also detected in platelets. species (ROS) generation and the impaired platelet activation as- More recently, NOX5 is found expressed in platelets from patients special-propertyTH sociated with VPS34 (vacuolar protein sorting 34) deficiency are with chronic granulomatous disease although it may not present bona fide
Arteriosclerosis, Thrombosis, and Vascular Biology – Wolters Kluwer Health
Published: Mar 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera