Response by Liu and Hu to Letter Regarding Article, “Class III PI3K Positively Regulates Platelet Activation and Thrombosis via PI(3)P-Directed Function of NADPH Oxidase”

Response by Liu and Hu to Letter Regarding Article, “Class III PI3K Positively Regulates... Letter to the Editor Letters to the Editor will be published, if suitable, as space permits. They should not exceed 1000 words (typed double-spaced) in length and may be subject to editing or abridgment. Nevertheless, both our study and the study conducted by Response by Liu and Hu to Letter Regarding Delaney et al demonstrate that low dose agonists (thrombin, Article, “Class III PI3K Positively Regulates 0.018 U/mL and 0.025 U/mL; collagen, 0.5 μg/mL; or CRP, 0.5 Platelet Activation and Thrombosis via PI(3) μg/mL) still activate significant ROS generation in platelets de- P-Directed Function of NADPH Oxidase” ficiency of NOX1, NOX2, or VPS34, suggesting the existence of In Response: other mechanisms of ROS generation independent of these pro- We welcome the letter commenting on our recent study, 7,8 teins. The NOX family consists of 7 catalytic homologues, in which raised a question on whether the defective reactive oxygen addition to NOX1 and NOX2, NOX4 is also detected in platelets. species (ROS) generation and the impaired platelet activation as- More recently, NOX5 is found expressed in platelets from patients special-propertyTH sociated with VPS34 (vacuolar protein sorting 34) deficiency are with chronic granulomatous disease although it may not present bona fide http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis, Thrombosis, and Vascular Biology Wolters Kluwer Health

Response by Liu and Hu to Letter Regarding Article, “Class III PI3K Positively Regulates Platelet Activation and Thrombosis via PI(3)P-Directed Function of NADPH Oxidase”

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Publisher
Wolters Kluwer
Copyright
© 2018 American Heart Association, Inc.
ISSN
1079-5642
eISSN
1524-4636
D.O.I.
10.1161/ATVBAHA.118.310712
Publisher site
See Article on Publisher Site

Abstract

Letter to the Editor Letters to the Editor will be published, if suitable, as space permits. They should not exceed 1000 words (typed double-spaced) in length and may be subject to editing or abridgment. Nevertheless, both our study and the study conducted by Response by Liu and Hu to Letter Regarding Delaney et al demonstrate that low dose agonists (thrombin, Article, “Class III PI3K Positively Regulates 0.018 U/mL and 0.025 U/mL; collagen, 0.5 μg/mL; or CRP, 0.5 Platelet Activation and Thrombosis via PI(3) μg/mL) still activate significant ROS generation in platelets de- P-Directed Function of NADPH Oxidase” ficiency of NOX1, NOX2, or VPS34, suggesting the existence of In Response: other mechanisms of ROS generation independent of these pro- We welcome the letter commenting on our recent study, 7,8 teins. The NOX family consists of 7 catalytic homologues, in which raised a question on whether the defective reactive oxygen addition to NOX1 and NOX2, NOX4 is also detected in platelets. species (ROS) generation and the impaired platelet activation as- More recently, NOX5 is found expressed in platelets from patients special-propertyTH sociated with VPS34 (vacuolar protein sorting 34) deficiency are with chronic granulomatous disease although it may not present bona fide

Journal

Arteriosclerosis, Thrombosis, and Vascular BiologyWolters Kluwer Health

Published: Mar 1, 2018

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