Response by Feola et al to Letter Regarding Article, “Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers”

Response by Feola et al to Letter Regarding Article, “Localized Optogenetic Targeting of Rotors... RESPONSE TO LETTER TO THE EDITOR Response by Feola et al to Letter Regarding Article, “Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers” In Response: Iolanda Feola, MSc We thank Houston et al for their interest in our study. In their letter, they raise the Linda Volkers, PhD question whether the rotors and accompanied spiral waves observed in our study Rupamanjari Majumder, represent microreentrant circuits anchored to lines of conduction block/slowing (ie, PhD anatomical reentry), instead of reentrant activity around an unexcited, yet excitable Alexander Teplenin, MSc core region (ie, functional reentry). Their comment is based on a movie published Martin J. Schalij, MD, PhD on their website, showing high-resolution mapping, in an HL-1 culture, of reen- Alexander V. Panfilov, trant activity that seems anchored to microregions of conduction abnormalities. PhD Although appraisal of these data is difficult without a detailed description of meth- Antoine A.F. de Vries, PhD ods and results, we still would like to add our thoughts about the distinction be- Daniël A. Pijnappels, PhD tween functional and anatomical reentry on a cellular level. Heterogeneities, such as gradients in excitability, refractoriness, and nonhomogeneous distribution of cardiac fibroblasts may have a destabilizing effect on functional reentry http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Arrhythmia & Electrophysiology Wolters Kluwer Health

Response by Feola et al to Letter Regarding Article, “Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers”

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Publisher
Wolters Kluwer
Copyright
© 2018 American Heart Association, Inc.
ISSN
1941-3149
eISSN
1941-3084
D.O.I.
10.1161/CIRCEP.117.006130
Publisher site
See Article on Publisher Site

Abstract

RESPONSE TO LETTER TO THE EDITOR Response by Feola et al to Letter Regarding Article, “Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers” In Response: Iolanda Feola, MSc We thank Houston et al for their interest in our study. In their letter, they raise the Linda Volkers, PhD question whether the rotors and accompanied spiral waves observed in our study Rupamanjari Majumder, represent microreentrant circuits anchored to lines of conduction block/slowing (ie, PhD anatomical reentry), instead of reentrant activity around an unexcited, yet excitable Alexander Teplenin, MSc core region (ie, functional reentry). Their comment is based on a movie published Martin J. Schalij, MD, PhD on their website, showing high-resolution mapping, in an HL-1 culture, of reen- Alexander V. Panfilov, trant activity that seems anchored to microregions of conduction abnormalities. PhD Although appraisal of these data is difficult without a detailed description of meth- Antoine A.F. de Vries, PhD ods and results, we still would like to add our thoughts about the distinction be- Daniël A. Pijnappels, PhD tween functional and anatomical reentry on a cellular level. Heterogeneities, such as gradients in excitability, refractoriness, and nonhomogeneous distribution of cardiac fibroblasts may have a destabilizing effect on functional reentry

Journal

Circulation: Arrhythmia & ElectrophysiologyWolters Kluwer Health

Published: Feb 1, 2018

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