Repolarization Reserve and Action Potential Dynamics in Failing Myocytes

Repolarization Reserve and Action Potential Dynamics in Failing Myocytes EDITORIAL Repolarization Reserve and Action Potential Dynamics in Failing Myocytes See Article by Hegyi et al Ji-Dong Fu, PhD Kenneth R. Laurita, PhD rolongation of action potential duration (APD) is typically observed in iso- lated myocytes from both humans and animals with heart failure (HF) and Pis generally thought to be an important arrhythmia substrate. Traditionally, + 2+ voltage-clamp studies have found that in addition to increased Na /Ca exchange + + and late Na currents, repolarizing currents, including the inward rectifier K (I ) K1 + 1,2 and delayed rectifier K (I , I ) currents, are decreased in HF. These changes Ks Kr are expected to significantly prolong repolarization; however, this is not often ob- 3 4 served at faster beating rates in failing myocytes and HF patients. In this issue of the Journal, Hegyi et al contend that more physiological conditions are required to understand the mechanisms of repolarization dynamics in HF myocytes. To this end, they used an elegant action potential (AP)–clamp technique to unravel the + 6 role and regulation of K currents under more realistic physiological conditions. Hegyi et al report that when more realistic physiological conditions are used 2+ by leaving Ca cycling http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Arrhythmia & Electrophysiology Wolters Kluwer Health

Repolarization Reserve and Action Potential Dynamics in Failing Myocytes

Loading next page...
 
/lp/wolters_kluwer/repolarization-reserve-and-action-potential-dynamics-in-failing-Z4cVGYeEvT
Publisher
Wolters Kluwer Health
Copyright
© 2018 American Heart Association, Inc.
ISSN
1941-3149
eISSN
1941-3084
D.O.I.
10.1161/CIRCEP.118.006137
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL Repolarization Reserve and Action Potential Dynamics in Failing Myocytes See Article by Hegyi et al Ji-Dong Fu, PhD Kenneth R. Laurita, PhD rolongation of action potential duration (APD) is typically observed in iso- lated myocytes from both humans and animals with heart failure (HF) and Pis generally thought to be an important arrhythmia substrate. Traditionally, + 2+ voltage-clamp studies have found that in addition to increased Na /Ca exchange + + and late Na currents, repolarizing currents, including the inward rectifier K (I ) K1 + 1,2 and delayed rectifier K (I , I ) currents, are decreased in HF. These changes Ks Kr are expected to significantly prolong repolarization; however, this is not often ob- 3 4 served at faster beating rates in failing myocytes and HF patients. In this issue of the Journal, Hegyi et al contend that more physiological conditions are required to understand the mechanisms of repolarization dynamics in HF myocytes. To this end, they used an elegant action potential (AP)–clamp technique to unravel the + 6 role and regulation of K currents under more realistic physiological conditions. Hegyi et al report that when more realistic physiological conditions are used 2+ by leaving Ca cycling

Journal

Circulation: Arrhythmia & ElectrophysiologyWolters Kluwer Health

Published: Feb 1, 2018

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off