Correspondence discuss the putative pitfalls of a Guytonian interpretation of salt sensitivity of blood pressure, including the lack of a b differences in sodium balance, plasma volume and cardiac Theodore W. Kurtz , Stephen E. DiCarlo , c d output between salt-sensitive and salt-resistant individuals Michal Pravenec , and R. Curtis Morris Jr given a salt load. We have also published on this . We would, therefore, suggest if these authors continue their crusade against ‘Guytonian dogma’ that they comment on e thank Drs Laffer and Elijovich for their interest new and important evidence. This includes the fact that salt  in our publication  focusing on the Amer- sensitivity can be experimentally produced by manipulat- W ican Heart Association (AHA) Scientific State- ing genes that are exclusively expressed in the kidney, ment on salt sensitivity . To our knowledge, our without expression or known function in the vasculature, publication is the first to criticize the AHA Statement  such as uromodulin , and also by specific renal proximal as it pertains to the pathogenesis of salt sensitivity. We tubular knockout of other genes, which remain normally highlighted the point that all of the putative abnormalities expressed systemically, such
Journal of Hypertension – Wolters Kluwer Health
Published: Mar 1, 2018
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