Reply to Letter to The Editor Regarding the COBRA Trial: What Will it Take to Perform High-quality Hernia Research?

Reply to Letter to The Editor Regarding the COBRA Trial: What Will it Take to Perform... Annals of Surgery  Volume 267, Number 3, March 2018 Letters to the Editor about the larger population from which the United States in an effort to develop lack of a control group limits any firm con- sample was taken. A commonly reported met- additional clinical data and understand lo- clusions as to the effect of the device on the ric in this regard is the 95% confidence interval ng-term outcomes in ventral hernia globally. outcomes that we measured in the study, and (CI), and its absence from Fig. 1 makes The success of these efforts demands that we that was clearly listed as a limitation in the interpretation difficult. For example, ‘‘a wide not only understand the data, but have keen discussion. We would, however, point out confidence interval points to a lack of infor- interest in the methods and their limitations. that this study represents the first scientific mation’’ and the potential for overinterpreting investigation of a bioabsorbable mesh in the Disclosures: DM and RS are both these findings. setting of complex abdominal wall recon- employees of ACELITY. Health-related quality of life (HRQoL) struction. Given that there are no prior pub- is also critically important, and this http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Surgery Wolters Kluwer Health

Reply to Letter to The Editor Regarding the COBRA Trial: What Will it Take to Perform High-quality Hernia Research?

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Publisher
Wolters Kluwer Health
Copyright
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
0003-4932
eISSN
1528-1140
D.O.I.
10.1097/SLA.0000000000002108
Publisher site
See Article on Publisher Site

Abstract

Annals of Surgery  Volume 267, Number 3, March 2018 Letters to the Editor about the larger population from which the United States in an effort to develop lack of a control group limits any firm con- sample was taken. A commonly reported met- additional clinical data and understand lo- clusions as to the effect of the device on the ric in this regard is the 95% confidence interval ng-term outcomes in ventral hernia globally. outcomes that we measured in the study, and (CI), and its absence from Fig. 1 makes The success of these efforts demands that we that was clearly listed as a limitation in the interpretation difficult. For example, ‘‘a wide not only understand the data, but have keen discussion. We would, however, point out confidence interval points to a lack of infor- interest in the methods and their limitations. that this study represents the first scientific mation’’ and the potential for overinterpreting investigation of a bioabsorbable mesh in the Disclosures: DM and RS are both these findings. setting of complex abdominal wall recon- employees of ACELITY. Health-related quality of life (HRQoL) struction. Given that there are no prior pub- is also critically important, and this

Journal

Annals of SurgeryWolters Kluwer Health

Published: Mar 1, 2018

References

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