Letter to the Editor However, the medications might signiﬁcantly affect the Red blood cell distribution width: a potential short-term mortality of patients admitted to the ED for AD prognostic index for short-term mortality of of liver cirrhosis. Furthermore, some medications may also patients admitted to emergency department affect the RDW levels . Thus, more details of the patients’ for acute decompensation of liver cirrhosis? medications would have been beneﬁcial. Therefore, prospective studies with well-deﬁned inclu- Rui Huang, Juan Xia, Jian Wang, Zhaoping Zhang and Chao Wu, Department sion and exclusion criteria are required to validate the of Infectious Diseases, Nanjing Drum Tower Hospital, the Afﬁliated Hospital of predictive values of RDW for the risk of short-term mor- Nanjing University Medical School, Nanjing, Jiangsu Province, China tality of AD patients of liver cirrhosis after ED admission. Correspondence to Chao Wu, MD, PhD, Department of Infectious Diseases, Nanjing Drum Tower Hospital, the Afﬁliated Hospital of Nanjing University Medical Acknowledgements School, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China Tel: + 86 25 8310 5890; fax: + 86 25 8330 7115; e-mail: firstname.lastname@example.org The study was supported by the National Natural Science Foundation of China (81672025 and 81702011), Medical Science and Technology Development Foundation of Nanjing (ZDX16004 and YKK16118), Jiangsu Provincial Received 31 October 2017 Accepted 3 November 2017 Medical Innovation Team (CXTDA2017005), Natural Science Foundation of Jiangsu Province for Young Scholar (BK20160121) and Nanjing Medical Science and We read with great interest the article by Turcato et al. . Technique Development Foundation (QRX17121). They conducted a retrospective study to explore the predictive values of red blood cell distribution width (RDW) for the risk of short-term mortality of patients admitted to the emergency Conﬂicts of interest department (ED) for acute decompensation (AD) of liver There are no conﬂicts of interest. cirrhosis . They concluded that RDW could independently predict 1-month mortality of patients with AD cirrhosis admitted to the ED . The study is very interesting. However, References we feel that several issues deserve further discussion. 1 Turcato G, Campagnaro T, Bonora A, Vignola N, Salvagno GL, RDW is an inexpensive parameter which reﬂects Cervellin G, et al. Red blood cell distribution width independently predicts volume heterogeneity of circulating erythrocytes and has 1-month mortality in acute decompensation of cirrhotic patients admitted to emergency department. Eur J Gastroenterol Hepatol 2018; 30:33–38. received growing attention. However, the RDW levels are 2 Karagöz E, Tanoglu A. Red blood cell distribution width: a potential easily affected by many confounding factors such as age prognostic index for liver disease? Clin Chem Lab Med 2014; 52: and malnutrition . Furthermore, RDW has been e201. demonstrated to be an independent index of prognosis in 3 Allen LA, Felker GM, Mehra MR, Chiong JR, Dunlap SH, Ghali JK, et al. Validation and potential mechanisms of red cell distribution width as a patients with several cardiovascular diseases such as heart prognostic marker in heart failure. J Card Fail 2010; 16:230–238. failure, myocardial infarction and stroke [3–5]. As pre- 4 Dabbah S, Hammerman H, Markiewicz W, Aronson D. Relation between sented in table 1, by the univariate analysis, the numbers of red cell distribution width and clinical outcomes after acute myocardial patients with comorbidity of heart failure between the infarction. Am J Cardiol 2010; 105:312–327. survived patients and those who died within 30 days after 5 Fan L, Gui L, Chai EQ, Wei CJ. Routine hematological parameters are associated with short- and long-term prognosis of patients with ED admission were signiﬁcantly different. Thus, the results ischemic stroke. J Clin Lab Anal 2017. [Epub ahead of print]. would be more convincing if the author had excluded 6 Fici F, Celik T, Balta S, Iyisoy A, Unlu M, Demitkol S, et al. Comparative patients with comorbidities of cardiovascular diseases such effects of nebivolol and metoprolol on red cell distribution width and as heart failure or added these comorbidities in the neutrophil/lymphocyte ratio in patients with newly diagnosed essential hypertension. J Cardiovasc Pharmacol 2013; 62:388–393. multivariate analysis. In addition, the medications for AD patients of liver cirrhosis after ED admission were not provided in the study. DOI: 10.1097/MEG.0000000000001042 European Journal of Gastroenterology & Hepatology 2018, 30:328 0954-691X Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. 328 Copyright r 2018 Wolters Kluwer Health, Inc. All rights reserved.
European Journal of Gastroenterology & Hepatology – Wolters Kluwer Health
Published: Mar 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera