Abstract The increased utilization of immunosuppressive, antineoplastic agents in patients with hematologic malignancies and hematopoietic stem cell transplant recipients impairs humoral and cellular immunity. As a result, susceptibility to infectious diseases, including reactivation/development of tuberculosis and its dissemination to extrapulmonary sites, is a serious concern. Tuberculosis dissemination to extrapulmonary sites can mimic both clinical and radiological presentations of other etiologic agents. Thus, early diagnosis is often challenging. We present 3 cases of tuberculosis infection, of which 2 disseminated to extrapulmonary sites in patients with hematologic malignancies, along with literature review, clinical presentation, diagnostic evaluation, and differential diagnosis.
Infectious Diseases in Clinical Practice – Wolters Kluwer Health
Published: Apr 1, 2017
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