Journal of Trauma and Acute Care Surgery, Publish Ahead of Print DOI: 10.1097/TA.0000000000001714 Re: Three versus four-factor prothrombin complex concentrates for “factor- based” resuscitation in a porcine hemorrhagic shock model Oliver Grottke Department of Anesthesiology, RWTH Aachen University Hospital, Aachen, Germany Address for correspondence: Oliver Grottke, MD PhD, Department of Anesthesiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany. Phone: +49 241 8080972; Facsimile: +49 241 8082406; Email: firstname.lastname@example.org Sources of Funding: None Conflicts of interest: OG has received research funding from Bayer Healthcare, Boehringer Ingelheim, Haemonetics, Novo Nordisk, Biotest, CSL Behring, Nycomed, Pfizer and Portola. OG has also received honoraria for lectures and consultancy support from Bayer Healthcare, Boehringer Ingelheim, CSL Behring, Octapharma, Shire, Sanofi, Pfizer and Portola. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. ACCEPTED In reporting their study of 3- and 4-factor prothrombin complex concentrate (PCC) in hemorrhagic shock and coagulopathy, Moe et al. have made an important contribution to the question whether PCCs can be used as an alternative to therapeutic plasma in trauma-related bleeding. Compared with therapeutic plasma, coagulation factor concentrates provide much higher concentrations of coagulation factors, enabling treatment with smaller infusion volumes. Coagulation factor concentrates can also be
The Journal of Trauma and Acute Care Surgery – Wolters Kluwer Health
Published: Apr 1, 2017
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