Questions Regarding Statistical Inferences, Quality of Life, and Conclusions From the COBRA Study

Questions Regarding Statistical Inferences, Quality of Life, and Conclusions From the COBRA Study Letters to the Editor Annals of Surgery  Volume 267, Number 3, March 2018 would facilitate the use of miRNA-based easy to score, this is a powerful design. The Outcomes Research (DM) for ACELITY, screening strategy in clinical settings. risk of biased selection is almost completely we acknowledge and value addressing the avoided by consecutively including all ‘‘clinical data gap’’ in ventral hernia repair. Disclosure: The authors declare no patients, incomplete blinding is never an issue We believe it is equally important that studies conflicts of interest. and optimal external validity ensured. The are conducted and reported with appropriate magnitude of effect ‘across the nation’ is also methodological rigor. The aim of our letter is much better preserved in the design used by to provide surgeons and other study Kecheng Zhang, MD McMillan’s trial and this is an evidence reviewers a deeper and clearer understanding Lin Chen, MD modality that has received too little attention of the recently published complex open bio- Department of General Surgery, People’s compared with evidence of ‘cause-and-effect’ absorbable reconstruction of the abdominal Liberation Army General Hospital that is the raison d’etre of the explanatory wall (COBRA) study. In particular, we high- Beijing, China RCT. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Surgery Wolters Kluwer Health

Questions Regarding Statistical Inferences, Quality of Life, and Conclusions From the COBRA Study

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Publisher
Wolters Kluwer
Copyright
Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc.
ISSN
0003-4932
eISSN
1528-1140
D.O.I.
10.1097/SLA.0000000000002107
Publisher site
See Article on Publisher Site

Abstract

Letters to the Editor Annals of Surgery  Volume 267, Number 3, March 2018 would facilitate the use of miRNA-based easy to score, this is a powerful design. The Outcomes Research (DM) for ACELITY, screening strategy in clinical settings. risk of biased selection is almost completely we acknowledge and value addressing the avoided by consecutively including all ‘‘clinical data gap’’ in ventral hernia repair. Disclosure: The authors declare no patients, incomplete blinding is never an issue We believe it is equally important that studies conflicts of interest. and optimal external validity ensured. The are conducted and reported with appropriate magnitude of effect ‘across the nation’ is also methodological rigor. The aim of our letter is much better preserved in the design used by to provide surgeons and other study Kecheng Zhang, MD McMillan’s trial and this is an evidence reviewers a deeper and clearer understanding Lin Chen, MD modality that has received too little attention of the recently published complex open bio- Department of General Surgery, People’s compared with evidence of ‘cause-and-effect’ absorbable reconstruction of the abdominal Liberation Army General Hospital that is the raison d’etre of the explanatory wall (COBRA) study. In particular, we high- Beijing, China RCT.

Journal

Annals of SurgeryWolters Kluwer Health

Published: Mar 1, 2018

References

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