Prognostic role of platelet to lymphocyte ratio in pancreatic cancers

Prognostic role of platelet to lymphocyte ratio in pancreatic cancers AbstractBackground:Platelet to lymphocyte ratio (PLR) was recently reported being associated with the prognosis of pancreatic cancer (PC), but the prognostic value of PLR in pancreatic cancer remains inconsistent. We conduct a meta-analysis to evaluate the prognostic role of PLR in patients with PC.Methods:PubMed, Embase, Cochrane Library, and Web of Science were systematically searched for eligible studies which investigated the relationship between PLR and clinical outcome of patients with pancreatic cancer. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the prognostic role of PLR in overall survival (OS) and progression-free survival (PFS)/time to progression (TTP).Results:A total of 16 studies comprising 3028 patients with PC were enrolled in this meta-analysis. Pooled analysis demonstrated that elevated PLR predicted a poor OS (HR = 1.22, 95% CI: 1.09–1.36, P < .001). Prognostic role of PLR on OS were significant in subgroup of Asians (HR = 1.22, 95% CI: 1.11–1.34, P < .001), patients treated with chemotherapy (HR = 1.18, 95% CI: 1.04–1.35, P = .01) and mixed methods (HR = 1.29, 95% CI: 1.07–1.57, P = .009), American joint committee on cancer (AJCC) stage of III–IV (HR = 1.22, 95% CI: 1.09–1.36, P < .001), pathological subtype of pancreatic adenocarcinoma (HR = 1.21, 95% CI: 1.08–1.36, P = .001), and cut-off value of PLR ≥160 (HR = 1.48, 95% CI: 1.25–1.75, P < .001).Conclusions:An elevated PLR is associated with unfavorable overall survival in patients with pancreatic cancer. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Medicine Wolters Kluwer Health

Prognostic role of platelet to lymphocyte ratio in pancreatic cancers

Loading next page...
 
/lp/wolters_kluwer/prognostic-role-of-platelet-to-lymphocyte-ratio-in-pancreatic-cancers-yLPS80KaQJ
Publisher
Wolters Kluwer Health
Copyright
Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc.
ISSN
0025-7974
eISSN
1536-5964
D.O.I.
10.1097/MD.0000000000009616
Publisher site
See Article on Publisher Site

Abstract

AbstractBackground:Platelet to lymphocyte ratio (PLR) was recently reported being associated with the prognosis of pancreatic cancer (PC), but the prognostic value of PLR in pancreatic cancer remains inconsistent. We conduct a meta-analysis to evaluate the prognostic role of PLR in patients with PC.Methods:PubMed, Embase, Cochrane Library, and Web of Science were systematically searched for eligible studies which investigated the relationship between PLR and clinical outcome of patients with pancreatic cancer. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the prognostic role of PLR in overall survival (OS) and progression-free survival (PFS)/time to progression (TTP).Results:A total of 16 studies comprising 3028 patients with PC were enrolled in this meta-analysis. Pooled analysis demonstrated that elevated PLR predicted a poor OS (HR = 1.22, 95% CI: 1.09–1.36, P < .001). Prognostic role of PLR on OS were significant in subgroup of Asians (HR = 1.22, 95% CI: 1.11–1.34, P < .001), patients treated with chemotherapy (HR = 1.18, 95% CI: 1.04–1.35, P = .01) and mixed methods (HR = 1.29, 95% CI: 1.07–1.57, P = .009), American joint committee on cancer (AJCC) stage of III–IV (HR = 1.22, 95% CI: 1.09–1.36, P < .001), pathological subtype of pancreatic adenocarcinoma (HR = 1.21, 95% CI: 1.08–1.36, P = .001), and cut-off value of PLR ≥160 (HR = 1.48, 95% CI: 1.25–1.75, P < .001).Conclusions:An elevated PLR is associated with unfavorable overall survival in patients with pancreatic cancer.

Journal

MedicineWolters Kluwer Health

Published: Feb 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off