EDITORIAL Plasma MicroRNA Clusters in Human Left Ventricular Remodeling A Biomarker and Discovery Platform See Article by Shah et al Arun Padmanabhan, MD, PhD Saptarsi M. Haldar, MD mpaired cardiac function results in increased neurohormonal activity, a stress response initially mounted to augment cardiac output. However, chronic or ex- Icessive activity of the neurohormonal response contributes to progressive myo- cardial damage and the clinical manifestations of the heart failure (HF) syndrome. This myocardial injury leads to a vicious cycle of organ remodeling, wherein the shape, thickness, volume of the ventricular cavity, and the functional state of the cells populating the stressed heart are adversely altered in a manner that further 1,2 compromises cardiac performance. Early work in animal models of myocardial infarction demonstrated the pathophysiologic significance of cardiac remodeling and a role for neurohormonal blockade in its prevention and reversal. These find- ings were subsequently extended to humans with myocardial infarction–associated HF and cardiac dilation in the absence of HF, with the severity of remodeling serv- 3,4 ing as a poor prognostic indicator. Current guideline-directed medical therapy for HF is associated with regression of ventricular dilation and improvement of ejection fraction in a subset of patients, a process called left ventricular
Circulation: Heart Failure – Wolters Kluwer Health
Published: Feb 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
It’s easy to organize your research with our built-in tools.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud