CLINICAL VIGNETTES A Clinical Case he hyperpolarization-activated cyclic nucleotide-gated (HCN) cation (Na+/K+) Helge Servatius, MD currents (If/Ih) are generated by 4 members of the channel family (HCN1–4). Alessandro Porro, BS 2 3 TThese currents contribute to the pacemaker function in heart and brain. The Stephan A. Pless, PhD HCN4 current is known to play a crucial role in the automaticity of the sinus node André Schaller, PhD through the generation of a slow diastolic depolarization during the phase 4 of the Babken Asatryan, MD cardiac action potential. Thus, it is a crucial channel for appropriate pacemaker activity Hildegard Tanner, MD and conduction system function because it facilitates rapid repolarization. Interestingly, Stefano F. de Marchi, MD HCN4 has been shown to be expressed in essentially the entire heart tissue. Mutations Laurent Roten, MD in HCN4 have been associated mainly with sick sinus syndrome phenotype ; however, Jens Seiler, MD in recent years, a broad spectrum of phenotypes has been reported, including sinus Andreas Haeberlin, MD, 7 8 9,10 bradycardia, inappropriate sinus tachycardia, early-onset atrial fibrillation, atrio- PhD 11,12 13 ventricular block, idiopathic ventricular tachycardia, left ventricular noncompac- Samuel H. Baldinger, MD 14–17 19 tion (LVNC), dilation of the aorta, and
Circulation: Cardiovascular Genetics – Wolters Kluwer Health
Published: Feb 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera