Olanzapine-induced peripheral eosinophilia and eosinophilic pleural effusion

Olanzapine-induced peripheral eosinophilia and eosinophilic pleural effusion AbstractRationale:Eosinophilic pleural effusion (EPE) is an eosinophil count ≥10% in pleural effusion, which is a rare condition in drug therapy.Patient concerns:We describe the case of a 70-year-old Alzheimer patient who was taking olanzapine for 2 months for the treatment of depression, and developed peripheral eosinophilia and bilateral EPE.Diagnoses:Olanzapine-induced peripheral eosinophilia and eosinophilic pleural effusion was diagnosed.Interventions:Olanzapine was discontinued, and repeated drainage of fluid from the pleural cavity was performed.Outcomes:All symptoms—as well as the EPE—were resolved 6 months later.Lessons:This case is a reminder that olanzapine may be a potential agent for EPE, and that this should be considered in clinical practice. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Medicine Wolters Kluwer Health

Olanzapine-induced peripheral eosinophilia and eosinophilic pleural effusion

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Publisher
Wolters Kluwer
Copyright
Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc.
ISSN
0025-7974
eISSN
1536-5964
D.O.I.
10.1097/MD.0000000000009996
Publisher site
See Article on Publisher Site

Abstract

AbstractRationale:Eosinophilic pleural effusion (EPE) is an eosinophil count ≥10% in pleural effusion, which is a rare condition in drug therapy.Patient concerns:We describe the case of a 70-year-old Alzheimer patient who was taking olanzapine for 2 months for the treatment of depression, and developed peripheral eosinophilia and bilateral EPE.Diagnoses:Olanzapine-induced peripheral eosinophilia and eosinophilic pleural effusion was diagnosed.Interventions:Olanzapine was discontinued, and repeated drainage of fluid from the pleural cavity was performed.Outcomes:All symptoms—as well as the EPE—were resolved 6 months later.Lessons:This case is a reminder that olanzapine may be a potential agent for EPE, and that this should be considered in clinical practice.

Journal

MedicineWolters Kluwer Health

Published: Feb 1, 2018

References

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