Myocardial Scar Is Prevalent and Associated With Subclinical Myocardial Dysfunction in Women With Suspected Ischemia But No Obstructive Coronary Artery Disease

Myocardial Scar Is Prevalent and Associated With Subclinical Myocardial Dysfunction in Women With... Circulation RESEARCH LETTER Myocardial Scar Is Prevalent and Associated With Subclinical Myocardial Dysfunction in Women With Suspected Ischemia But No Obstructive Coronary Artery Disease From the Women’s Ischemia Syndrome Evaluation–Coronary Vascular Dysfunction Study omen with suspected ischemia and no obstructive coronary artery dis- Janet Wei, MD ease (INOCA) have a high prevalence of coronary microvascular dysfunc- May Bakir, MD Wtion and an elevated rate of major adverse cardiac events, including Navid Darounian, MD nonfatal myocardial infarction (MI). Cardiac magnetic resonance (CMR) with late Quanlin Li, MS gadolinium enhancement (LGE) imaging accurately visualizes and characterizes Sofy Landes, MD myocardial scar, which predicts major adverse cardiac events. The prevalence, in- Puja K. Mehta, MD cidence, and scar pattern in women with INOCA is not well characterized. We Chrisandra L. Shufelt, MD evaluated LGE in women with suspected INOCA in the WISE-CVD study (Women’s Eileen M. Handberg, PhD Ischemia Syndrome Evaluation–Coronary Vascular Dysfunction; URL: http://www. Sheryl F. Kelsey, MD clinicaltrials.gov. Unique identifier: NCT00832702). George Sopko, MD Participants in the WISE-CVD study included women with suspected INOCA as Carl J. Pepine, MD previously described. The study was approved by the site institutional review com- John W. Petersen, MD mittees. All participants gave informed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation Wolters Kluwer Health

Myocardial Scar Is Prevalent and Associated With Subclinical Myocardial Dysfunction in Women With Suspected Ischemia But No Obstructive Coronary Artery Disease

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Publisher
Wolters Kluwer Health
Copyright
© 2018 American Heart Association, Inc.
ISSN
0009-7322
eISSN
1524-4539
D.O.I.
10.1161/CIRCULATIONAHA.117.031999
Publisher site
See Article on Publisher Site

Abstract

Circulation RESEARCH LETTER Myocardial Scar Is Prevalent and Associated With Subclinical Myocardial Dysfunction in Women With Suspected Ischemia But No Obstructive Coronary Artery Disease From the Women’s Ischemia Syndrome Evaluation–Coronary Vascular Dysfunction Study omen with suspected ischemia and no obstructive coronary artery dis- Janet Wei, MD ease (INOCA) have a high prevalence of coronary microvascular dysfunc- May Bakir, MD Wtion and an elevated rate of major adverse cardiac events, including Navid Darounian, MD nonfatal myocardial infarction (MI). Cardiac magnetic resonance (CMR) with late Quanlin Li, MS gadolinium enhancement (LGE) imaging accurately visualizes and characterizes Sofy Landes, MD myocardial scar, which predicts major adverse cardiac events. The prevalence, in- Puja K. Mehta, MD cidence, and scar pattern in women with INOCA is not well characterized. We Chrisandra L. Shufelt, MD evaluated LGE in women with suspected INOCA in the WISE-CVD study (Women’s Eileen M. Handberg, PhD Ischemia Syndrome Evaluation–Coronary Vascular Dysfunction; URL: http://www. Sheryl F. Kelsey, MD clinicaltrials.gov. Unique identifier: NCT00832702). George Sopko, MD Participants in the WISE-CVD study included women with suspected INOCA as Carl J. Pepine, MD previously described. The study was approved by the site institutional review com- John W. Petersen, MD mittees. All participants gave informed

Journal

CirculationWolters Kluwer Health

Published: Feb 20, 2018

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