Mitochondrial DNA in Acute Kidney Injury: Chicken or Egg?

Mitochondrial DNA in Acute Kidney Injury: Chicken or Egg? SHOCK, Vol. 49, No. 3, pp. 352–353, 2018 Editorial Comment * * Lukas Martin and Christoph Thiemermann Queen Mary University London, The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK; and Department of Intensive Care and Intermediate Care, University Hospital RWTH Aachen, Aachen, Germany Received 26 Jul 2017; accepted in final form 4 Aug 2017 It happens every day in hospitals around the world. A patient their levels to markers of renal impairment, inflammation, arrives in the emergency department with severe injuries, burns, coagulation, and platelet activation. In addition, the authors or a medical condition that requires major surgery. After challenged mice (in vivo) and murine, primary renal tubular undergoing surgery (and sometimes massive blood transfusion) epithelial cells and platelets (ex vivo) with mtDNA or purified treatment continues in the intensive care unit. After hours or mitochondrial ligands. days, the patient develops multiple organ failure (i.e., lung, In line with the results from an earlier study (4), the authors liver, heart, or kidney) in the absence of any sign of infection. found that plasma levels of mtDNA were increased in SIRS; This serious, but common, phenomenon raises the question, however, the presence http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png SHOCK®: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches Wolters Kluwer Health

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Publisher
Wolters Kluwer
Copyright
Copyright © 2017 by the Shock Society
ISSN
1073-2322
eISSN
1540-0514
D.O.I.
10.1097/SHK.0000000000000966
Publisher site
See Article on Publisher Site

Abstract

SHOCK, Vol. 49, No. 3, pp. 352–353, 2018 Editorial Comment * * Lukas Martin and Christoph Thiemermann Queen Mary University London, The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK; and Department of Intensive Care and Intermediate Care, University Hospital RWTH Aachen, Aachen, Germany Received 26 Jul 2017; accepted in final form 4 Aug 2017 It happens every day in hospitals around the world. A patient their levels to markers of renal impairment, inflammation, arrives in the emergency department with severe injuries, burns, coagulation, and platelet activation. In addition, the authors or a medical condition that requires major surgery. After challenged mice (in vivo) and murine, primary renal tubular undergoing surgery (and sometimes massive blood transfusion) epithelial cells and platelets (ex vivo) with mtDNA or purified treatment continues in the intensive care unit. After hours or mitochondrial ligands. days, the patient develops multiple organ failure (i.e., lung, In line with the results from an earlier study (4), the authors liver, heart, or kidney) in the absence of any sign of infection. found that plasma levels of mtDNA were increased in SIRS; This serious, but common, phenomenon raises the question, however, the presence

Journal

SHOCK®: Injury, Inflammation, and Sepsis: Laboratory and Clinical ApproachesWolters Kluwer Health

Published: Mar 1, 2018

References

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