Long-term Administration of Salicylate-induced Changes in BDNF Expression and CREB Phosphorylation in the Auditory Cortex of Rats

Long-term Administration of Salicylate-induced Changes in BDNF Expression and CREB... Hypothesis:We investigated whether salicylate induces tinnitus through alteration of the expression levels of brain-derived neurotrophic factor (BDNF), proBDNF, tyrosine kinase receptor B (TrkB), cAMP-responsive element-binding protein (CREB), and phosphorylated CREB (p-CREB) in the auditory cortex (AC).Background:Salicylate medication is frequently used for long-term treatment in clinical settings, but it may cause reversible tinnitus. Salicylate-induced tinnitus is associated with changes related to central auditory neuroplasticity. Our previous studies revealed enhanced neural activity and ultrastructural synaptic changes in the central auditory system after long-term salicylate administration. However, the underlying mechanisms remained unclear.Methods:Salicylate-induced tinnitus-like behavior in rats was confirmed using gap prepulse inhibition of acoustic startle and prepulse inhibition testing, followed by comparison of the expression levels of BDNF, proBDNF, TrkB, CREB, and p-CREB. Synaptic ultrastructure was observed under a transmission electron microscope.Results:BDNF and p-CREB were upregulated along with ultrastructural changes at the synapses in the AC of rats treated chronically with salicylate (p < 0.05, compared with control group). These changes returned to normal after 14 days of recovery (p > 0.05).Conclusion:Long-term administration of salicylate increased BDNF expression and CREB activation, upregulated synaptic efficacy, and changed synaptic ultrastructure in the AC. There may be a relationship between these factors and the mechanism of tinnitus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Otology & Neurotology Wolters Kluwer Health

Long-term Administration of Salicylate-induced Changes in BDNF Expression and CREB Phosphorylation in the Auditory Cortex of Rats

8 pages
Read Article

Loading next page...
 
/lp/wolters_kluwer/long-term-administration-of-salicylate-induced-changes-in-bdnf-qWkNsO1K0F
Publisher
Wolters Kluwer
Copyright
Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of Otology & Neurotology, Inc.
ISSN
1531-7129
eISSN
1537-4505
D.O.I.
10.1097/MAO.0000000000001717
Publisher site
See Article on Publisher Site

Abstract

Hypothesis:We investigated whether salicylate induces tinnitus through alteration of the expression levels of brain-derived neurotrophic factor (BDNF), proBDNF, tyrosine kinase receptor B (TrkB), cAMP-responsive element-binding protein (CREB), and phosphorylated CREB (p-CREB) in the auditory cortex (AC).Background:Salicylate medication is frequently used for long-term treatment in clinical settings, but it may cause reversible tinnitus. Salicylate-induced tinnitus is associated with changes related to central auditory neuroplasticity. Our previous studies revealed enhanced neural activity and ultrastructural synaptic changes in the central auditory system after long-term salicylate administration. However, the underlying mechanisms remained unclear.Methods:Salicylate-induced tinnitus-like behavior in rats was confirmed using gap prepulse inhibition of acoustic startle and prepulse inhibition testing, followed by comparison of the expression levels of BDNF, proBDNF, TrkB, CREB, and p-CREB. Synaptic ultrastructure was observed under a transmission electron microscope.Results:BDNF and p-CREB were upregulated along with ultrastructural changes at the synapses in the AC of rats treated chronically with salicylate (p < 0.05, compared with control group). These changes returned to normal after 14 days of recovery (p > 0.05).Conclusion:Long-term administration of salicylate increased BDNF expression and CREB activation, upregulated synaptic efficacy, and changed synaptic ultrastructure in the AC. There may be a relationship between these factors and the mechanism of tinnitus.

Journal

Otology & Neurotology – Wolters Kluwer Health

Published: Mar 1, 2018

References

  • Phantom auditory sensation in rats: an animal model for tinnitus
  • Alterations in average spectrum of cochleoneural activity by long-term salicylate treatment in the guinea pig: a plausible index of tinnitus
  • Expression of immediate-early genes in the inferior colliculus and auditory cortex in salicylate-induced tinnitus in rat
  • Tinnitus and headache
  • Measurement” of tinnitus
  • Tinnitus treatment trends
  • Paradoxical enhancement of active cochlear mechanics in long-term administration of salicylate
  • Stably maintained dendritic spines are associated with lifelong memories
  • Average spectrum of cochlear activity: a possible synchronized firing, its olivo-cochlear feedback and alterations under anesthesia
  • Tinnitus: causes and clinical management
  • Tinnitus
  • Tinnitus: perspectives from human neuroimaging
  • BDNF-induced local protein synthesis and synaptic plasticity
  • Form follows function: BDNF and its involvement in sculpting the function and structure of synapses
  • Ultrasound enhances the expression of brain-derived neurotrophic factor in astrocyte through activation of TrkB-Akt and calcium-CaMK signaling pathways
  • Shc-binding site in the TrkB receptor is not required for hippocampal long-term potentiation
  • Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity
  • Understanding proneurotrophin actions: recent advances and challenges
  • Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity
  • Neuroanatomical tracing techniques in the ear: history, state of the art, and future developments
  • Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression
  • PLCgamma-activated signalling is essential for TrkB mediated sensory neuron structural plasticity
  • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
  • Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism
  • Tinnitus: the mechanism of tinnitus centralization and clinical management
  • Effects of salicylate on the inflammatory genes expression and synaptic ultrastructure in the cochlear nucleus of rats
  • Expression of immediate-early genes in the dorsal cochlear nucleus in salicylate-induced tinnitus
  • Effects of long-term salicylate administration on synaptic ultrastructure and metabolic activity in the rat CNS
  • Reversing pathological neural activity using targeted plasticity
  • Effects of furosemide on cochlear neural activity, central hyperactivity and behavioural tinnitus after cochlear trauma in guinea pig
  • Altered neuronal intrinsic properties and reduced synaptic transmission of the rat's medial geniculate body in salicylate-induced tinnitus
  • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
  • Role of synaptic structural plasticity in impairments of spatial learning and memory induced by developmental lead exposure in Wistar rats
  • Differential effects of protein synthesis inhibition on the activity-dependent expression of BDNF transcripts: evidence for immediate-early gene responses from specific promoters
  • Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons
  • Salicylate ototoxicity; a clinical and experimental study
  • Behavioral model of chronic tinnitus in rats
  • Flufenamic acid prevents behavioral manifestations of salicylate-induced tinnitus in the rat
  • Midazolam reverses salicylate-induced changes in brain-derived neurotrophic factor and arg3.1 expression: implications for tinnitus perception and auditory plasticity
  • Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus
  • Tinnitus and depression
  • GDNF and BDNF gene interplay in chronic tinnitus
  • Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus
  • Plasma brain-derived neurotrophic factor levels are increased in patients with tinnitus and correlated with therapeutic effects
  • Regulation of brain-derived neurotrophic factor-mediated transcription of the immediate early gene Arc by intracellular calcium and calmodulin
  • BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development
  • Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons
  • BDNF regulates the expression and distribution of vesicular glutamate transporters in cultured hippocampal neurons
  • Rab3A is required for brain-derived neurotrophic factor-induced synaptic plasticity: transcriptional analysis at the population and single-cell levels
  • Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
  • Cleavage of proBDNF to BDNF by a tolloid-like metalloproteinase is required for acquisition of in vitro eyeblink classical conditioning
  • The molecular biology of memory storage: a dialogue between genes and synapses
  • Clozapine blockade of MK-801-induced learning/memory impairment in the mEPM: Role of 5-HT1A receptors and hippocampal BDNF levels
  • Neurotrophins: to cleave or not to cleave
  • The yin and yang of neurotrophin action
  • CREB: a major mediator of neuronal neurotrophin responses
  • PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine
  • Chondroitinase enhances cortical map plasticity and increases functionally active sprouting axons after brain injury
  • c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration
  • Time-dependent co-relation of BDNF and CREB mRNAs in adult rat brains following acute psychological stress in the communication box paradigm
  • Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication
  • Salicylate alters the expression of calcium response transcription factor 1 in the cochlea: implications for brain-derived neurotrophic factor transcriptional regulation
  • Salicylate enables cochlear arachidonic-acid-sensitive NMDA receptor responses
  • Essential role of presynaptic NMDA receptors in activity-dependent BDNF secretion and corticostriatal LTP
  • In vivo CREB phosphorylation mediated by dopamine and NMDA receptor activation in mouse hippocampus and caudate nucleus
  • Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from Google Scholar, PubMed
Create lists to organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off