LETTER TO THE EDITOR Letter by Houston et al Regarding Article, “Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers” To the Editor: Charles Houston, MRes We read with great interest the article by Feola et al on investigating the mechanisms Fu Siong Ng, MRCP, PhD of rotor-guided ablation through optogenetic stimulation in monolayers of neonatal rat Emmanuel Dupont, PhD atrial cardiomyocytes. The authors optically map single stable rotors which could be re- liably initiated in their homogeneous monolayers and report on the success rate of dif- ferent light ablation approaches to terminate the rotors by localized conduction block. We previously studied similar rotor activity using high spatiotemporal resolu- tion optical mapping in monolayers of functionally homogeneous atrial murine cells (HL1-6 myocytes ). At similar mapping resolutions to this work, we also ob- serve apparent spiral waves characteristic of rotor theory. On mapping the cores of our rotors at higher single-cell resolution (2.6×2.6 μm per pixel), we found that the activity was instead driven by microreentry around lines of conduction block/ slowing with lengths 200 to 800 μm (http://wwwf.imperial.ac.uk/imedia/content/ view/6049; Houston C, MRes and Dupont E, PhD, unpublished data, 2017). These lengths correlate with the regularity of the macro
Circulation: Arrhythmia & Electrophysiology – Wolters Kluwer Health
Published: Feb 1, 2018
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