Letter by Houston et al Regarding Article, “Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers”

Letter by Houston et al Regarding Article, “Localized Optogenetic Targeting of Rotors in Atrial... LETTER TO THE EDITOR Letter by Houston et al Regarding Article, “Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers” To the Editor: Charles Houston, MRes We read with great interest the article by Feola et al on investigating the mechanisms Fu Siong Ng, MRCP, PhD of rotor-guided ablation through optogenetic stimulation in monolayers of neonatal rat Emmanuel Dupont, PhD atrial cardiomyocytes. The authors optically map single stable rotors which could be re- liably initiated in their homogeneous monolayers and report on the success rate of dif- ferent light ablation approaches to terminate the rotors by localized conduction block. We previously studied similar rotor activity using high spatiotemporal resolu- tion optical mapping in monolayers of functionally homogeneous atrial murine cells (HL1-6 myocytes ). At similar mapping resolutions to this work, we also ob- serve apparent spiral waves characteristic of rotor theory. On mapping the cores of our rotors at higher single-cell resolution (2.6×2.6 μm per pixel), we found that the activity was instead driven by microreentry around lines of conduction block/ slowing with lengths 200 to 800 μm (http://wwwf.imperial.ac.uk/imedia/content/ view/6049; Houston C, MRes and Dupont E, PhD, unpublished data, 2017). These lengths correlate with the regularity of the macro http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Arrhythmia & Electrophysiology Wolters Kluwer Health

Letter by Houston et al Regarding Article, “Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers”

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Publisher
Wolters Kluwer Health
Copyright
© 2018 American Heart Association, Inc.
ISSN
1941-3149
eISSN
1941-3084
D.O.I.
10.1161/CIRCEP.117.006118
Publisher site
See Article on Publisher Site

Abstract

LETTER TO THE EDITOR Letter by Houston et al Regarding Article, “Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers” To the Editor: Charles Houston, MRes We read with great interest the article by Feola et al on investigating the mechanisms Fu Siong Ng, MRCP, PhD of rotor-guided ablation through optogenetic stimulation in monolayers of neonatal rat Emmanuel Dupont, PhD atrial cardiomyocytes. The authors optically map single stable rotors which could be re- liably initiated in their homogeneous monolayers and report on the success rate of dif- ferent light ablation approaches to terminate the rotors by localized conduction block. We previously studied similar rotor activity using high spatiotemporal resolu- tion optical mapping in monolayers of functionally homogeneous atrial murine cells (HL1-6 myocytes ). At similar mapping resolutions to this work, we also ob- serve apparent spiral waves characteristic of rotor theory. On mapping the cores of our rotors at higher single-cell resolution (2.6×2.6 μm per pixel), we found that the activity was instead driven by microreentry around lines of conduction block/ slowing with lengths 200 to 800 μm (http://wwwf.imperial.ac.uk/imedia/content/ view/6049; Houston C, MRes and Dupont E, PhD, unpublished data, 2017). These lengths correlate with the regularity of the macro

Journal

Circulation: Arrhythmia & ElectrophysiologyWolters Kluwer Health

Published: Feb 1, 2018

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