LETTERS TO THE EDITOR Recently, I have reported that human to establish mature-form islets in ad- Human Fetal β Islets Express pancreatic islets develop through fusion be- vanced fusion? Do the β islets remain Coagulation Factor XIII-A tween 2 distinct precursor islets, β and α/δ passive in the process? For the questions, islets. The β islets consist of only insulin- I raised a hypothesis that the β islets and Proteases Suggesting producing cells, whereas the α/δ islets consist regulated the fusion by secreting nonendo- Amphicrine Regulation to of intermixed glucagon- and somatostatin- crine soluble factors. In this study, po- Facilitate Islet Fusion producing cells. They are evidently discern- tential soluble factor candidates were able on hematoxylin and eosin sections. screened in human fetal pancreatic islets The β islets are global in shape surrounded using immunohistochemistry. by well-developed fibrous capsule. In con- Formalin-fixed and paraffin-embedded To the Editor: trast, the α/δ islets are variable in shape and tissue samples of 36 fetal autopsies, ranging ancreatic islet development has been incompletely encapsulated, suggesting an from 12 to 29 weeks of gestational age, were P a subject of intense biomedical inter- active mobility. As the α/δ islets adjoin collected randomly from pathology
Pancreas – Wolters Kluwer Health
Published: Jan 1, 2018
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