Human Fetal β Islets Express Coagulation Factor XIII-A and Proteases Suggesting Amphicrine Regulation to Facilitate Islet Fusion

Human Fetal β Islets Express Coagulation Factor XIII-A and Proteases Suggesting Amphicrine... LETTERS TO THE EDITOR Recently, I have reported that human to establish mature-form islets in ad- Human Fetal β Islets Express pancreatic islets develop through fusion be- vanced fusion? Do the β islets remain Coagulation Factor XIII-A tween 2 distinct precursor islets, β and α/δ passive in the process? For the questions, islets. The β islets consist of only insulin- I raised a hypothesis that the β islets and Proteases Suggesting producing cells, whereas the α/δ islets consist regulated the fusion by secreting nonendo- Amphicrine Regulation to of intermixed glucagon- and somatostatin- crine soluble factors. In this study, po- Facilitate Islet Fusion producing cells. They are evidently discern- tential soluble factor candidates were able on hematoxylin and eosin sections. screened in human fetal pancreatic islets The β islets are global in shape surrounded using immunohistochemistry. by well-developed fibrous capsule. In con- Formalin-fixed and paraffin-embedded To the Editor: trast, the α/δ islets are variable in shape and tissue samples of 36 fetal autopsies, ranging ancreatic islet development has been incompletely encapsulated, suggesting an from 12 to 29 weeks of gestational age, were P a subject of intense biomedical inter- active mobility. As the α/δ islets adjoin collected randomly from pathology http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pancreas Wolters Kluwer Health

Human Fetal β Islets Express Coagulation Factor XIII-A and Proteases Suggesting Amphicrine Regulation to Facilitate Islet Fusion

Pancreas , Volume 47 (3) – Jan 1, 2018

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Publisher
Wolters Kluwer Health
Copyright
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
0885-3177
eISSN
1536-4828
D.O.I.
10.1097/MPA.0000000000000996
Publisher site
See Article on Publisher Site

Abstract

LETTERS TO THE EDITOR Recently, I have reported that human to establish mature-form islets in ad- Human Fetal β Islets Express pancreatic islets develop through fusion be- vanced fusion? Do the β islets remain Coagulation Factor XIII-A tween 2 distinct precursor islets, β and α/δ passive in the process? For the questions, islets. The β islets consist of only insulin- I raised a hypothesis that the β islets and Proteases Suggesting producing cells, whereas the α/δ islets consist regulated the fusion by secreting nonendo- Amphicrine Regulation to of intermixed glucagon- and somatostatin- crine soluble factors. In this study, po- Facilitate Islet Fusion producing cells. They are evidently discern- tential soluble factor candidates were able on hematoxylin and eosin sections. screened in human fetal pancreatic islets The β islets are global in shape surrounded using immunohistochemistry. by well-developed fibrous capsule. In con- Formalin-fixed and paraffin-embedded To the Editor: trast, the α/δ islets are variable in shape and tissue samples of 36 fetal autopsies, ranging ancreatic islet development has been incompletely encapsulated, suggesting an from 12 to 29 weeks of gestational age, were P a subject of intense biomedical inter- active mobility. As the α/δ islets adjoin collected randomly from pathology

Journal

PancreasWolters Kluwer Health

Published: Jan 1, 2018

References

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