LETTERS TO THE EDITOR Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome in a Child With Klinefelter Syndrome To the Editor: Klinefelter syndrome is charac- terized by gynecomastia, hypogonad- ism, small testes, elevated levels of FIGURE 1. Bone marrow aspiration smear of the patient. follicle-stimulating hormone and an extra X chromosome (ie, 47,XXY). These patients tend to have an increased risk of developing male analysis—both from bone marrow and focal opacities with ground—glass den- breast cancer and mediastinal germ cell peripheral blood—which demonstrated sities in superior segment of inferior lobe 2,3 tumors. Hematologic malignancies 47,XXY karyotype led to the diagnosis of the right lung. He was diagnosed with including acute or chronic leukemia of Klinefelter syndrome. Chest compu- bronchiolitis obliterans. He beneﬁted from are also observed in these patients, but terized tomography was consistent with formoterol fumarate clinically and his only a few case reports with Klinefelter pulmonary infection and the patient respiratory function tests improved. There syndrome who developed myelo- was given broad spectrum antibiotics was not any evidence of chronic graft dysplastic syndrome (MDS) were (vancomycin, meropenem, amikacin, versus host disease other than bronchioli- 4–7 published. clarithromycin, and trimethoprim sulfa- tis obliterans. At 8 years of follow-up, An
Journal of Pediatric Hematology / Oncology – Wolters Kluwer Health
Published: Jan 1, 2018
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