EDITORIAL URRENT Gallstone disease, towards a better understanding PINION and clinical practice a,b Chantal Housset Among all digestive diseases, gallstone disease is the (NAFLD) have been identified as potential targets, in most common and costly one, with an estimated the prevention of cholesterol gallstone disease. Arr- prevalence of 10–20% in the Western world. Symp- ese et al. herein describe the frequent association tomatic disease is responsible for 1.4 million visits and bidirectional relationship between gallstone and 750 000 cholecystectomies per year in the disease and NAFLD. Insulin resistance, a well estab- United States. The vast majority of gallstones (more lished key event in the development and progres- than 75%) are of cholesterol or cholesterol-predom- sion of NAFLD, has also been shown to cause inant type. In this issue of Current Opinion in cholesterol gallstone formation. In addition, apart Gastroenterology, Shabanzadeh reports on the epi- from common risk factors, NAFLD has been identi- demiology of gallstone disease on the basis of ultra- fied as an independent risk factor of gallstone sound screening, notably in population cohorts disease. Conversely gallstone disease and cholecys- unaware of the presence of gallstones. These studies tectomy have an impact on the development and indicate that
Current Opinion in Gastroenterology – Wolters Kluwer Health
Published: Mar 1, 2018
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