EDITORIAL Broadening the Focus of Cardiovascular Innovation See Article by Sangaralingham et al Nalini A. Colaco, MD, PhD Dhruv S. Kazi, MD, MSc, n July 7, 2015, sacubitril/valsartan became the first angiotensin receptor- MS neprilysin inhibitor approved by the US Food and Drug Administration for Ouse among patients with symptomatic heart failure with reduced ejection fraction (HFrEF). This expedited approval was based on the results of the PARA- DIGM-HF trial (Prospective Comparison of ARNI with ACE-I to Determine Impact on Global Mortality and Morbidity in Heart Failure) that showed that among pa- tients with New York Heart Association class II–IV heart failure and ejection fraction ≤40%, treatment with sacubitril/valsartan rather than 10 mg twice daily of enalapril produced a 17.7% reduction in the composite end point of cardiovascular mor- tality and hospitalizations for heart failure. The study demonstrated a remarkable 19.4% reduction in death from cardiovascular causes and 17.9% reduction in heart failure hospitalizations among patients receiving sacubitril/valsartan compared with those receiving enalapril. Sacubitril/valsartan is the first new-in-class medication to demonstrate a mortality benefit in patients with HFrEF since the early 2000s. In this issue of Circulation: Heart Failure, Sangaralingham et al describe the early experience with sacubitril/valsartan among
Circulation: Heart Failure – Wolters Kluwer Health
Published: Feb 1, 2018
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