Five-year serial follow-up of muscle MRI in adult onset myotonic dystrophy type 1

Five-year serial follow-up of muscle MRI in adult onset myotonic dystrophy type 1 AbstractRationale:Although several studies have described the involvement pattern of myotonic dystrophy type 1 (DM1) using muscle MRI, most of these studies have limitations as cross-sectional studies. To the best of our knowledge, there have been no reports of longitudinal studies describing muscle involvement patterns in patients with DM1 via serial MRI.Patient concerns:Progressive weakness of both lower extremities.Diagnosis:Two patients with DM1.Intervention:The serial muscle MRI performed in the 2 patients with DM1.Outcomes:The serial muscle MRI showed early involvement of proximal (tensor fascia latae) and truncal muscles (spine extensor muscles), and these longitudinal imaging may be helpful to reveal the pattern of muscle involvement in patients with DM1.Lessons:Since most previous studies on muscle involvement patterns in DM1 patients were cross-sectional studies, this case series of studying muscle involvement patterns through serial MRI in patients with DM1 may have significant clinical significance. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Medicine Wolters Kluwer Health

Five-year serial follow-up of muscle MRI in adult onset myotonic dystrophy type 1

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Publisher
Wolters Kluwer
Copyright
Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc.
ISSN
0025-7974
eISSN
1536-5964
D.O.I.
10.1097/MD.0000000000009379
Publisher site
See Article on Publisher Site

Abstract

AbstractRationale:Although several studies have described the involvement pattern of myotonic dystrophy type 1 (DM1) using muscle MRI, most of these studies have limitations as cross-sectional studies. To the best of our knowledge, there have been no reports of longitudinal studies describing muscle involvement patterns in patients with DM1 via serial MRI.Patient concerns:Progressive weakness of both lower extremities.Diagnosis:Two patients with DM1.Intervention:The serial muscle MRI performed in the 2 patients with DM1.Outcomes:The serial muscle MRI showed early involvement of proximal (tensor fascia latae) and truncal muscles (spine extensor muscles), and these longitudinal imaging may be helpful to reveal the pattern of muscle involvement in patients with DM1.Lessons:Since most previous studies on muscle involvement patterns in DM1 patients were cross-sectional studies, this case series of studying muscle involvement patterns through serial MRI in patients with DM1 may have significant clinical significance.

Journal

MedicineWolters Kluwer Health

Published: Jan 1, 2018

References

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