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Family History and Risk of Fatal Prostate Cancer

Family History and Risk of Fatal Prostate Cancer To examine the relation between fatal prostate cancer and family history of prostate cancer in a first‐degree relative, we analyzed data from a prospective mortality study of 481,011 men with no history of cancer at enrollment in 1982. During 9 years of follow‐up, 1,922 deaths from prostate cancer occurred. Results from Cox proportional hazard models showed that family history of prostate cancer was related to fatal prostate cancer [rate ratio (RR) = 1.60; 95% confidence interval (CI) = 1.31–1.97]; men with two or more affected relatives had a greater than threefold increase in risk (RR = 3.19; 95% CI = 1.51–6.71). Men whose relatives were diagnosed with prostate cancer before age 65 years (RR = 2.03; 95% CI = 1.33–3.09) had a greater effect of family history than men whose relatives were diagnosed at older ages (RR = 1.50; 95% CI = 1.17–1.91). Rate ratios did not increase with decreasing age of the study participants. The 60% increase in risk for men with at least one affected relative is lower than that reported in previous studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Epidemiology Wolters Kluwer Health

Family History and Risk of Fatal Prostate Cancer

Epidemiology , Volume 8 (6) – Nov 1, 1997

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Copyright
© 1997 by Epidemiology Resources Inc.
ISSN
1044-3983
eISSN
1531-5487

Abstract

To examine the relation between fatal prostate cancer and family history of prostate cancer in a first‐degree relative, we analyzed data from a prospective mortality study of 481,011 men with no history of cancer at enrollment in 1982. During 9 years of follow‐up, 1,922 deaths from prostate cancer occurred. Results from Cox proportional hazard models showed that family history of prostate cancer was related to fatal prostate cancer [rate ratio (RR) = 1.60; 95% confidence interval (CI) = 1.31–1.97]; men with two or more affected relatives had a greater than threefold increase in risk (RR = 3.19; 95% CI = 1.51–6.71). Men whose relatives were diagnosed with prostate cancer before age 65 years (RR = 2.03; 95% CI = 1.33–3.09) had a greater effect of family history than men whose relatives were diagnosed at older ages (RR = 1.50; 95% CI = 1.17–1.91). Rate ratios did not increase with decreasing age of the study participants. The 60% increase in risk for men with at least one affected relative is lower than that reported in previous studies.

Journal

EpidemiologyWolters Kluwer Health

Published: Nov 1, 1997

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