Comparison of intravenous and oral acetaminophen for pain control after total knee and hip arthroplasty

Comparison of intravenous and oral acetaminophen for pain control after total knee and hip... AbstractObjective:To evaluate the efficacy between intravenous and oral acetaminophen as adjunct to multimodal analgesia regimens for pain management after total knee and hip arthroplasties.Methods:We conduct electronic searches of Medline (1966–2017.09), PubMed (1966–2017.09), Embase (1980–2017.09), ScienceDirect (1985–2017.09), and the Cochrane Library. Only randomized controlled trials (RCTs) are included. The quality assessment is performed according to the Cochrane systematic review method. Fixed/random effect model is adopted according to the heterogeneity tested by I2 statistic. Meta-analysis is performed using Stata 11.0 software.Results:Two RCTs are included involving 236 patients. The present meta-analysis demonstrated that there were no significant differences between groups regarding pain scores at 12, 24, or 48 hours. No significant differences were observed in terms of opioid consumption at 12, 24, or 48 hours after arthroplasties.Conclusion:Intravenous acetaminophen to multimodal analgesia dose not demonstrate a significant benefit in reducing pain and opioid consumption compared oral formulation after total knee arthroplasty and total hip arthroplasty. Higher-quality RCTs are required for further research. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Medicine Wolters Kluwer Health

Comparison of intravenous and oral acetaminophen for pain control after total knee and hip arthroplasty

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Publisher
Wolters Kluwer
Copyright
Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc.
ISSN
0025-7974
eISSN
1536-5964
D.O.I.
10.1097/MD.0000000000009751
Publisher site
See Article on Publisher Site

Abstract

AbstractObjective:To evaluate the efficacy between intravenous and oral acetaminophen as adjunct to multimodal analgesia regimens for pain management after total knee and hip arthroplasties.Methods:We conduct electronic searches of Medline (1966–2017.09), PubMed (1966–2017.09), Embase (1980–2017.09), ScienceDirect (1985–2017.09), and the Cochrane Library. Only randomized controlled trials (RCTs) are included. The quality assessment is performed according to the Cochrane systematic review method. Fixed/random effect model is adopted according to the heterogeneity tested by I2 statistic. Meta-analysis is performed using Stata 11.0 software.Results:Two RCTs are included involving 236 patients. The present meta-analysis demonstrated that there were no significant differences between groups regarding pain scores at 12, 24, or 48 hours. No significant differences were observed in terms of opioid consumption at 12, 24, or 48 hours after arthroplasties.Conclusion:Intravenous acetaminophen to multimodal analgesia dose not demonstrate a significant benefit in reducing pain and opioid consumption compared oral formulation after total knee arthroplasty and total hip arthroplasty. Higher-quality RCTs are required for further research.

Journal

MedicineWolters Kluwer Health

Published: Feb 1, 2018

References

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