Invited Commentaries JPGN Volume 66, Number 3, March 2018 intestinal microbiota in some subjects (8). Fecal microbiome CFTR mutations with none to minimal residual protein transplant from these 4 NNS ‘‘responders’’ transferred the glucose function clinically present with exocrine pancreas insufficiency intolerance. The mechanisms that contribute to this apparent and are classified as severe mutations (4). Already in a early phase metabolic response to NNS in some people are unclear, but of disease development, often already in utero, the exocrine pan- certainly larger randomized trials are warranted. Bacteria do have creatic tissue is structurally destroyed due to autophagic and the ability to metabolize sucralose and sucralose has been shown to autolytic activity leading up to the complete inability to excrete have a bacteriostatic effect on some bacteria. Notably other NNS the proteolytic and lipolytic digestive pancreatic enzymes. As a can alter the gut microbiome and impair glucose tolerance in result of the structural nature of the damage, the production and humans and, in the case of aspartame, in doses that are compatible secretion of exocrine pancreatic enzymes are permanently blocked with human intake (10). and stopped. Remarkably, however, this inability of CF patients to The evidence for harm from
Journal of Pediatric Gastroenterology & Nutrition – Wolters Kluwer Health
Published: Mar 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera