CNE08.qxd:Layout 1 5/13/10 9:09 AM Page 1 VOLUME 32 • NUMBER 8 April 30, 2010 A BIWEEKLY PUBLICATION FOR CLINICAL NEUROSURGICAL CONTINUING MEDICAL EDUCATION Central Nervous System Hemangioblastomas Part I: Incidence Anand Veeravagu, MD, Bowen Jiang, BS, Jason Moss, BA, John Sinclair, MD, and Steven D. Chang, MD Learning Objectives: After participating in this activity, the neurosurgeon should be better able to: 1. Analyze the incidence of central nervous system hemangioblastomas associated with von Hippel-Lindau (VHL) disease. 2. Distinguish the histologic characteristics of central nervous system hemangioblastomas associated with VHL disease. 3. Evaluate the genetic basis of VHL disease. This article is the first of four parts. Histologically, hemangioblastomas are vascular lesions containing channels lined by cuboidal epithelium and are History, Classification, and Pathology interspersed with nests of foamy stromal cells and peri- Central nervous system (CNS) hemangioblastomas in the cytes. Mast cells also are found and may be responsible for cerebellum were first described by Jackson in 1872. Heman- the production of erythropoietin, which can cause ery- gioblastomas are slow-growing tumors that account for 1% throcytosis (Figure 2). Although debate continues, the clus- to 3% of all CNS neoplasms and 7% to 10% of posterior fossa ters of
Contemporary Neurosurgery – Wolters Kluwer Health
Published: Apr 1, 2010
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