β-Blocker use is associated with a higher relapse risk of inflammatory bowel disease: a Dutch retrospective case–control study

β-Blocker use is associated with a higher relapse risk of inflammatory bowel disease: a Dutch... ObjectiveInflammatory bowel disease (IBD) is a multifactorial disease and many factors may influence the disease course, like the concomitant use of medication. An example thereof is the use of β-blockers, antagonizing β-adrenergic receptors. β-adrenergic receptor activation has potent anti-inflammatory effects on the immune system. We addressed whether an association exists between the use of beta-blockers and the course of IBD, defined by the risk of a disease relapse in patients with IBD.Patients and methodsIn this retrospective case–control study, we used a population-based cohort of patients with IBD. We identified colitis relapses using IBD medication prescriptions as a proxy. We calculated the number of relapses per 100 person-years and compared this between patients with IBD using β-blockers and patients with IBD not using β-blockers. We used Cox proportional hazards models with shared frailty to compare the relative relapse risk between both groups.ResultsA total of 250 patients with IBD were included, of which 30 patients used a β-blocker for at least 3 months. With the Cox proportional hazards model with shared frailty, adjusted for age and sex, we observed a 54% (hazard ratio: 1.54; 95% confidence interval: 1.05–2.25; P=0.03) higher risk of a relapse in the group of patients with IBD using β-blockers versus the group not using β-blockers.ConclusionEven in this limited cohort study, we show that patients with IBD using β-blockers have an increased relapse risk. Indeed, concomitant medication use seems to be a factor that can influence the course of IBD, and this should be acknowledged while making decisions about treatment of IBD and follow-up. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Gastroenterology & Hepatology Wolters Kluwer Health

β-Blocker use is associated with a higher relapse risk of inflammatory bowel disease: a Dutch retrospective case–control study

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Publisher
Wolters Kluwer
Copyright
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
0954-691X
eISSN
1473-5687
D.O.I.
10.1097/MEG.0000000000001016
Publisher site
See Article on Publisher Site

Abstract

ObjectiveInflammatory bowel disease (IBD) is a multifactorial disease and many factors may influence the disease course, like the concomitant use of medication. An example thereof is the use of β-blockers, antagonizing β-adrenergic receptors. β-adrenergic receptor activation has potent anti-inflammatory effects on the immune system. We addressed whether an association exists between the use of beta-blockers and the course of IBD, defined by the risk of a disease relapse in patients with IBD.Patients and methodsIn this retrospective case–control study, we used a population-based cohort of patients with IBD. We identified colitis relapses using IBD medication prescriptions as a proxy. We calculated the number of relapses per 100 person-years and compared this between patients with IBD using β-blockers and patients with IBD not using β-blockers. We used Cox proportional hazards models with shared frailty to compare the relative relapse risk between both groups.ResultsA total of 250 patients with IBD were included, of which 30 patients used a β-blocker for at least 3 months. With the Cox proportional hazards model with shared frailty, adjusted for age and sex, we observed a 54% (hazard ratio: 1.54; 95% confidence interval: 1.05–2.25; P=0.03) higher risk of a relapse in the group of patients with IBD using β-blockers versus the group not using β-blockers.ConclusionEven in this limited cohort study, we show that patients with IBD using β-blockers have an increased relapse risk. Indeed, concomitant medication use seems to be a factor that can influence the course of IBD, and this should be acknowledged while making decisions about treatment of IBD and follow-up.

Journal

European Journal of Gastroenterology & HepatologyWolters Kluwer Health

Published: Feb 1, 2018

References

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