RESEARCH LETTER BCL2L11 Is Associated With Kawasaki Disease in Intravenous Immunoglobulin Responder Patients awasaki disease (KD) is a self-limited systemic vasculitis of an unknown Young-Chang Kwon, PhD pathogenesis mainly affecting children <5 years old. KD is a clinically hetero- Jae-Jung Kim, PhD K geneous disease; its diagnosis is based on common clinical symptoms, and Sin Weon Yun, MD, PhD there is no specific diagnostic test for it. Complete KD is diagnosed when subjects Jeong Jin Yu, MD, PhD have at least 5 of the following 6 principal clinical signs: fever persisting for ≥5 Kyung Lim Yoon, MD, PhD days, bilateral conjunctival congestion, changes to the lips and oral cavity, poly- Kyung-Yil Lee, MD, PhD morphous exanthema, changes to peripheral extremities, and acute nonpurulent Hong-Ryang Kil, MD, PhD cervical lymphadenopathy. Gi Beom Kim, MD, PhD The standard treatment for KD is high-dose intravenous immunoglobulin (IVIG), Myung-Ki Han, MD manufactured from normal human immunoglobulin purified from the full plasma Min Seob Song, MD, PhD of a thousand healthy donors; it reduces the duration of fever and the incidence Hyoung Doo Lee, MD, PhD of coronary artery abnormalities. The anti-inflammatory effects of IVIG are mani- Kee Soo Ha, MD, PhD fested in
Circulation: Cardiovascular Genetics – Wolters Kluwer Health
Published: Feb 1, 2018
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