Arrhythmic Risk Stratification for Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmic Risk Stratification for Arrhythmogenic Right Ventricular Cardiomyopathy EDITORIAL Arrhythmic Risk Stratification for Arrhythmogenic Right Ventricular Cardiomyopathy Should We Ask Who Is at High Risk or Who Is at Low Risk? See Article by Orgeron et al Julia H. Indik, MD, PhD rrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive disorder characterized by morphological changes in the myocardium that Aplace the patient at risk for lethal ventricular arrhythmias. A genetic muta- tion involving desmosomes is seen in most patients that affects myocyte cell-to- cell adhesion. Athletes are likely to express this disease at an earlier age as exercise promotes progression of the disease. Because either ventricle can be affected, the 1,2 term arrhythmogenic cardiomyopathy has been proposed. Diagnosis is based on criteria as set out in the 2010 Task Force document, encompassing ventricular structure, histology, electrocardiographic features, arrhythmias, and genetic fea- tures. In 2015, an International Task Force published a consensus statement to pro- vide clinical practice guidance based on available evidence and expert opinion. For implantable cardioverter defibrillator (ICD) implantation, the Task Force as- signed a class I recommendation to patients who had been resuscitated from he- modynamically unstable ventricular tachycardia (VT) or ventricular fibrillation (VF) and for patients with severe right ventricular or left ventricular systolic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Arrhythmia & Electrophysiology Wolters Kluwer Health

Arrhythmic Risk Stratification for Arrhythmogenic Right Ventricular Cardiomyopathy

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Publisher
Wolters Kluwer Health
Copyright
© 2018 American Heart Association, Inc.
ISSN
1941-3149
eISSN
1941-3084
D.O.I.
10.1161/CIRCEP.118.006160
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL Arrhythmic Risk Stratification for Arrhythmogenic Right Ventricular Cardiomyopathy Should We Ask Who Is at High Risk or Who Is at Low Risk? See Article by Orgeron et al Julia H. Indik, MD, PhD rrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive disorder characterized by morphological changes in the myocardium that Aplace the patient at risk for lethal ventricular arrhythmias. A genetic muta- tion involving desmosomes is seen in most patients that affects myocyte cell-to- cell adhesion. Athletes are likely to express this disease at an earlier age as exercise promotes progression of the disease. Because either ventricle can be affected, the 1,2 term arrhythmogenic cardiomyopathy has been proposed. Diagnosis is based on criteria as set out in the 2010 Task Force document, encompassing ventricular structure, histology, electrocardiographic features, arrhythmias, and genetic fea- tures. In 2015, an International Task Force published a consensus statement to pro- vide clinical practice guidance based on available evidence and expert opinion. For implantable cardioverter defibrillator (ICD) implantation, the Task Force as- signed a class I recommendation to patients who had been resuscitated from he- modynamically unstable ventricular tachycardia (VT) or ventricular fibrillation (VF) and for patients with severe right ventricular or left ventricular systolic

Journal

Circulation: Arrhythmia & ElectrophysiologyWolters Kluwer Health

Published: Feb 1, 2018

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