ABSTRACTS Abstracts Presented at the 10th Annual Meeting of the North American Neuroendocrine Tumor Society, October 19–21, 2017, Philadelphia, Pennsylvania therapy, and no prior exposure to a pyrrolobenzodiazepine-based drug. A 3+3 dose Immune Checkpoint Markers in Pulmonary Large Cell escalation is used in each cohort, at doses 0.2-0.4 mg/kg of Rova-T administered Neuroendocrine Carcinomas intravenously on Day 1 of each 42-day cycle, and proceeding until a maximum tolerated dose (MTD) is determined. A 2-stage design will be used for disease- Nagla Abdel Karim, Arun Sendilnathan, Ihab Eldessouki, Melissa Orr-Asman, specific expansion cohorts. Changchun Xie, Jiang Wang, Hala Elnakat Thomas. University of Cincinnati, Results: As of 3 April 2017, 31 pts (2 melanoma, 2 MTC, 3 GBM, 3 LCNEC, Cincinnati, OH. 3 NEPC, 3 GEP NEC, 10 other NEC, 5 other solid tumor) have been treated (26 Background: The overall prognosis for pulmonary large cell neuroendocrine pts at 0.2 mg/kg, 5 pts at 0.3 mg/kg Rova-T). MTD has not been reached. carcinoma (LCNEC) patients is poor despite treatment with front line systemic Twenty-six pts (84%) had an adverse event (AE), and only 3/31 pts (10%) chemotherapy regimens for small cell lung cancer (SCLC) or non-SCLC had a Grade 3+ AE
Pancreas – Wolters Kluwer Health
Published: Jan 1, 2018
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