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The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic Gastroparesis

The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and... Downloaded from http://journals.lww.com/ajg by BhDMf5ePHKbH4TTImqenVJ2toCr/9wZZjwPUWvYES9lBjFbu9i0DAnSw4JagSjiU on 10/29/2020 1382 THE RED SECTION nature publishing group The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic Gastroparesis 1 2 3 1 1 4 Pieter Janssen , PhD , M. Scott Harris , MD , Mike Jones , PhD , Tatsuhiro Masaoka , MD, PhD , Ricard Farr é , PhD , Hans T ö rnblom , MD, PhD , 1 4 1 Lukas Van Oudenhove , MD, PhD , Magnus Simr é n , MD, PhD and Jan Tack , MD, PhD OBJECTIVES: The relationship between symptom improvement (SI) and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain. In this paper we examined the study-specifi c correlations between SI and GE, and we performed a meta-regression analysis of the association across multiple studies. METHODS: The MEDLINE database (1,946 to present) was searched, and only controlled trials or trials with an established effective comparator that compared both SI and GE were included. RESULTS: Studies were identifi ed for metoclopramide ( n = 6), domperidone ( n = 6), cisapride ( n = 14), erythro- mycin ( http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Gastroenterology Wolters Kluwer Health

The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic Gastroparesis

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References (60)

Publisher
Wolters Kluwer Health
Copyright
© The American College of Gastroenterology 2013. All Rights Reserved.
ISSN
0002-9270
eISSN
1572-0241
DOI
10.1038/ajg.2013.118
Publisher site
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Abstract

Downloaded from http://journals.lww.com/ajg by BhDMf5ePHKbH4TTImqenVJ2toCr/9wZZjwPUWvYES9lBjFbu9i0DAnSw4JagSjiU on 10/29/2020 1382 THE RED SECTION nature publishing group The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic Gastroparesis 1 2 3 1 1 4 Pieter Janssen , PhD , M. Scott Harris , MD , Mike Jones , PhD , Tatsuhiro Masaoka , MD, PhD , Ricard Farr é , PhD , Hans T ö rnblom , MD, PhD , 1 4 1 Lukas Van Oudenhove , MD, PhD , Magnus Simr é n , MD, PhD and Jan Tack , MD, PhD OBJECTIVES: The relationship between symptom improvement (SI) and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain. In this paper we examined the study-specifi c correlations between SI and GE, and we performed a meta-regression analysis of the association across multiple studies. METHODS: The MEDLINE database (1,946 to present) was searched, and only controlled trials or trials with an established effective comparator that compared both SI and GE were included. RESULTS: Studies were identifi ed for metoclopramide ( n = 6), domperidone ( n = 6), cisapride ( n = 14), erythro- mycin (

Journal

American Journal of Gastroenterology – Wolters Kluwer Health

Published: Sep 1, 2013

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