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The Rapid Transformation of Transplantation for Corneal Endothelial Diseases: An Evolution From Penetrating to Lamellar to Cellular Transplants

The Rapid Transformation of Transplantation for Corneal Endothelial Diseases: An Evolution From... Downloaded from http://journals.lww.com/apjoo by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/04/2020 REVIEW ARTICLE The Rapid Transformation of Transplantation for Corneal Endothelial Diseases: An Evolution From Penetrating to Lamellar to Cellular Transplants Jie Zhang, PhD, Dipika V. Patel, PhD, MRCOphth, and Charles N.J. McGhee, DSc, FRCOphth Abstract: The cornea is the major focusing structure of the human eye orneal endothelial cells play a crucial role in regulating and the corneal endothelium maintains the relatively dehydrated state of corneal hydration. However, these cells are known to the cornea required for clarity. The endothelial cells respond to disease or undergo very little or no proliferation in vivo and typically injury by migration and cellular enlargement. Our current understanding respond to reduced density by migration and cellular enlarge- is that there is a very limited degree of proliferative or regenerative ment. Therefore, disease or injury to these cells may result in capacity in the human corneal endothelium. Thus, corneal endothelial corneal edema and loss of corneal transparency; hence, significant diseases may result in corneal edema, significantly impact vision and visual loss, including blindness, may occur. quality of life. Contemporary surgical transplantation options for treating Corneal endothelial diseases affect all ages, have a signifi- moderate to advanced endothelial http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Asia-Pacific Journal of Ophthalmology Wolters Kluwer Health

The Rapid Transformation of Transplantation for Corneal Endothelial Diseases: An Evolution From Penetrating to Lamellar to Cellular Transplants

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Publisher
Wolters Kluwer Health
ISSN
2162-0989
eISSN
2475-5028
DOI
10.1097/APO.0000000000000265
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Abstract

Downloaded from http://journals.lww.com/apjoo by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/04/2020 REVIEW ARTICLE The Rapid Transformation of Transplantation for Corneal Endothelial Diseases: An Evolution From Penetrating to Lamellar to Cellular Transplants Jie Zhang, PhD, Dipika V. Patel, PhD, MRCOphth, and Charles N.J. McGhee, DSc, FRCOphth Abstract: The cornea is the major focusing structure of the human eye orneal endothelial cells play a crucial role in regulating and the corneal endothelium maintains the relatively dehydrated state of corneal hydration. However, these cells are known to the cornea required for clarity. The endothelial cells respond to disease or undergo very little or no proliferation in vivo and typically injury by migration and cellular enlargement. Our current understanding respond to reduced density by migration and cellular enlarge- is that there is a very limited degree of proliferative or regenerative ment. Therefore, disease or injury to these cells may result in capacity in the human corneal endothelium. Thus, corneal endothelial corneal edema and loss of corneal transparency; hence, significant diseases may result in corneal edema, significantly impact vision and visual loss, including blindness, may occur. quality of life. Contemporary surgical transplantation options for treating Corneal endothelial diseases affect all ages, have a signifi- moderate to advanced endothelial

Journal

The Asia-Pacific Journal of Ophthalmology – Wolters Kluwer Health

Published: Nov 1, 2019

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