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ORIGINAL ARTICLE The Novel Protein Suppressed in Lung Cancer Down- Regulated in Lung Cancer Tissues Retards Cell Proliferation and Inhibits the Oncokinase Aurora-A Chang-Tze Ricky Yu, PhD,*† Jiun-Yi Hsia, MD,‡§ Yun-Chih Hseih, PhD,¶ Li-Jen Su, PhD,# Tien-Chiang Lee, Master,* Chia-Feng Ku, Master,* Ke-Shin Chen, Master,* Jou-May Maureen Chen, Master,* Tong-You Wade Wei, Master,* Yuan-Chii Gladys Lee, PhD,** Chi-Ying F. Huang, PhD,†† Yu-Chung Wu, MD,‡‡ Chiou-Ying Yang, PhD, and Shih-Lan Hsu, PhD¶§ activity of Aurora-A by directly inhibiting kinase activity in vitro or Introduction: In an attempt to search for genes with abnormal reducing the level of active Aurora-A in cells. SLAN is frequently expression in cancers, Suppressed in Lung Cancer (SLAN, also reduced in lung cancer tissues overexpressing Aurora-A, arguing for known as KIAA0256) is found underexpressed in human lung cancer the necessity to suppress SLAN during the Aurora-A-associated tissues by quantitative real-time PCR (Q-RT-PCR). The study set cancer formation. out to characterize SLAN protein and explore its cellular functions. Conclusions: Taken together, we have identified a novel protein Methods: SLAN or its specific short hairpin RNA, full length or SLAN downregulated in lung caner, having multiple subcellular various deletion mutants were overexpressed in 293T or lung cancer localization
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jun 1, 2011
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