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Hemodynamic parameters and systemic arterial compliance were measured in patients with arteriosclerosis obliterans of the lower limbs before and after acute administration of propranolol. Arterial compliance was evaluated from a simple viscoelastic model, enabling the calculation of diastoiic drainage and diastoiic blood flow as indices of the reservoir role of the large arteries in overall circulation, in comparing basal conditions with normal subjects of the same age, patients with arteriosclerosis obliterans exhibited a significant decrease in arterial compliance (p< 0.01) and heart rate (p< 0.02) with a significant increase in systolic pressure (p< 0.001). Diastoiic drainage was increased (p< 0.01) and was positively correlated with diastoiic time (r= 0.73, p< 0.001). Diastoiic blood flow remained within normal ranges (52 ± 2 vs 49 ± 3 ml/m2/sec). After acute propranolol intravenous administration, heart rate and stroke volume decreased (p< 0.001), while total peripheral resistance increased (p< 0.001). Systemic arterial compliance and diastoiic blood flow significantly decreased (p< 0.01). The study provided evidence that in patients with arteriosclerosis obliterans, the diastoiic blood flow was maintained in basal conditions despite the observed reduction in arterial compliance, and that intravenous propranolol administration decreased systemic arterial compliance and diastoiic blood flow.
Arteriosclerosis – Wolters Kluwer Health
Published: May 1, 1982
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