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ORIGINAL ARTICLE Reproducibility of Histopathological Diagnosis in Poorly Differentiated NSCLC An International Multiobserver Study Erik Thunnissen, MD, PhD,* Masayuki Noguchi, MD,† Seena Aisner, MD,‡ Mary Beth Beasley, MD,§ Elisabeth Brambilla, MD, PhD,║ Lucian R. Chirieac, MD,¶ Jin-Haeng Chung, MD, PhD,# Sanja Dacic, MD,** Kim R. Geisinger, MD,†† Fred R. Hirsch, MD, PhD,‡‡ Yuichi Ishikawa, MD, PhD,§§ Keith M. Kerr, MD, PhD,║ Sylvie Lantejoul, MD, PhD,¶¶ Yoshiro Matsuno, MD,## Yuko Minami, MD,*** Andre L. Moreira, MD,††† Giuseppe Pelosi, MD,‡‡‡ Iver Petersen, MD, PhD,§§§ Victor Roggli, MD,║║║ William D. Travis, MD,††† Ignacio Wistuba, MD,¶¶¶ Yasushi Yatabe, MD, PhD,### Rafal Dziadziuszko, MD, PhD,**** Birgit Witte, PhD,†††† Ming-Sound Tsao, MD, FRCPC,‡‡‡‡ and Andrew G. Nicholson, DM,§§§§ cell carcinoma. The goal of this study was first, to assess the reproduc- Introduction: The 2004 World Health Organization classification of ibility of a set of histopathological features for SqCC in relation to other lung cancer contained three major forms of non–small-cell lung cancer: poorly differentiated non–small-cell lung cancers and second, to assess squamous cell carcinoma (SqCC), adenocarcinoma (AdC), and large the value of immunohistochemistry in improving the diagnosis. Methods: Resection specimens (n = 37) with SqCC, large cell Departments of *Pathology and ††††Epidemiology and Biostatistics, VU carcinoma, basaloid carcinoma, sarcomatoid carcinoma, lympho-
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Sep 1, 2014
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