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Reproducibility of Histopathological Diagnosis in Poorly Differentiated NSCLC An International Multiobserver Study

Reproducibility of Histopathological Diagnosis in Poorly Differentiated NSCLC An International... ORIGINAL ARTICLE Reproducibility of Histopathological Diagnosis in Poorly  Differentiated NSCLC An International Multiobserver Study Erik Thunnissen, MD, PhD,* Masayuki Noguchi, MD,† Seena Aisner, MD,‡ Mary Beth Beasley, MD,§ Elisabeth Brambilla, MD, PhD,║ Lucian R. Chirieac, MD,¶ Jin-Haeng Chung, MD, PhD,# Sanja Dacic, MD,** Kim R. Geisinger, MD,†† Fred R. Hirsch, MD, PhD,‡‡ Yuichi Ishikawa, MD, PhD,§§ Keith M. Kerr, MD, PhD,║ Sylvie Lantejoul, MD, PhD,¶¶ Yoshiro Matsuno, MD,## Yuko Minami, MD,*** Andre L. Moreira, MD,††† Giuseppe Pelosi, MD,‡‡‡ Iver Petersen, MD, PhD,§§§ Victor Roggli, MD,║║║ William D. Travis, MD,††† Ignacio Wistuba, MD,¶¶¶ Yasushi Yatabe, MD, PhD,### Rafal Dziadziuszko, MD, PhD,**** Birgit Witte, PhD,†††† Ming-Sound Tsao, MD, FRCPC,‡‡‡‡ and Andrew G. Nicholson, DM,§§§§ cell carcinoma. The goal of this study was first, to assess the reproduc- Introduction: The 2004 World Health Organization classification of ibility of a set of histopathological features for SqCC in relation to other lung cancer contained three major forms of non–small-cell lung cancer: poorly differentiated non–small-cell lung cancers and second, to assess squamous cell carcinoma (SqCC), adenocarcinoma (AdC), and large the value of immunohistochemistry in improving the diagnosis. Methods: Resection specimens (n = 37) with SqCC, large cell Departments of *Pathology and ††††Epidemiology and Biostatistics, VU carcinoma, basaloid carcinoma, sarcomatoid carcinoma, lympho- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Reproducibility of Histopathological Diagnosis in Poorly Differentiated NSCLC An International Multiobserver Study

Journal of Thoracic Oncology , Volume 9 (9) – Sep 1, 2014

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References (28)

Copyright
Copyright © 2014 by the International Association for the Study of Lung Cancer
ISSN
1556-0864
DOI
10.1097/JTO.0000000000000264
pmid
25122431
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Reproducibility of Histopathological Diagnosis in Poorly  Differentiated NSCLC An International Multiobserver Study Erik Thunnissen, MD, PhD,* Masayuki Noguchi, MD,† Seena Aisner, MD,‡ Mary Beth Beasley, MD,§ Elisabeth Brambilla, MD, PhD,║ Lucian R. Chirieac, MD,¶ Jin-Haeng Chung, MD, PhD,# Sanja Dacic, MD,** Kim R. Geisinger, MD,†† Fred R. Hirsch, MD, PhD,‡‡ Yuichi Ishikawa, MD, PhD,§§ Keith M. Kerr, MD, PhD,║ Sylvie Lantejoul, MD, PhD,¶¶ Yoshiro Matsuno, MD,## Yuko Minami, MD,*** Andre L. Moreira, MD,††† Giuseppe Pelosi, MD,‡‡‡ Iver Petersen, MD, PhD,§§§ Victor Roggli, MD,║║║ William D. Travis, MD,††† Ignacio Wistuba, MD,¶¶¶ Yasushi Yatabe, MD, PhD,### Rafal Dziadziuszko, MD, PhD,**** Birgit Witte, PhD,†††† Ming-Sound Tsao, MD, FRCPC,‡‡‡‡ and Andrew G. Nicholson, DM,§§§§ cell carcinoma. The goal of this study was first, to assess the reproduc- Introduction: The 2004 World Health Organization classification of ibility of a set of histopathological features for SqCC in relation to other lung cancer contained three major forms of non–small-cell lung cancer: poorly differentiated non–small-cell lung cancers and second, to assess squamous cell carcinoma (SqCC), adenocarcinoma (AdC), and large the value of immunohistochemistry in improving the diagnosis. Methods: Resection specimens (n = 37) with SqCC, large cell Departments of *Pathology and ††††Epidemiology and Biostatistics, VU carcinoma, basaloid carcinoma, sarcomatoid carcinoma, lympho-

Journal

Journal of Thoracic OncologyWolters Kluwer Health

Published: Sep 1, 2014

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