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ORIGINAL ARTICLE Racial Differences in the Association Between SNPs on 15q25.1, Smoking Behavior, and Risk of Non-small Cell Lung Cancer Ann G. Schwartz, PhD,*† Michele L. Cote, PhD,*† Angela S. Wenzlaff, MPH,* Susan Land, PhD,‡§ and Christopher I. Amos, PhD ung cancer continues to be the leading cause of cancer Introduction: Three genome-wide association studies identified a Ldeath in the United States. Incidence rates are higher in region on chromosome 15q25.1 associated with lung cancer and African Americans than in whites, with average annual age- measures of nicotine addiction. This region includes nicotinic ace- adjusted rates, 2001 to 2005, at 50.3 and 41.3 per 100,000, tylcholine receptor subunit genes CHRNA3 and CHRNA5. These respectively. With more than 85% of lung cancer risk attrib- studies were conducted in European or European American popu- utable to cigarette smoking, this racial variation in incidence lations and do not provide risk estimates for African Americans. The occurs even though African Americans smoke fewer ciga- goal of this study was to determine whether recently identified rettes per day than whites. In addition, an understanding of genetic variation in 3 SNPs (rs1051730, rs931794, rs8034191) on the influence of genetic susceptibility is not fully appreciated. chromosome
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Oct 1, 2009
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