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Racial Differences in the Association Between SNPs on 15q25.1, Smoking Behavior, and Risk of Non-small Cell Lung Cancer

Racial Differences in the Association Between SNPs on 15q25.1, Smoking Behavior, and Risk of... ORIGINAL ARTICLE Racial Differences in the Association Between SNPs on 15q25.1, Smoking Behavior, and Risk of Non-small Cell Lung Cancer Ann G. Schwartz, PhD,*† Michele L. Cote, PhD,*† Angela S. Wenzlaff, MPH,* Susan Land, PhD,‡§ and Christopher I. Amos, PhD ung cancer continues to be the leading cause of cancer Introduction: Three genome-wide association studies identified a Ldeath in the United States. Incidence rates are higher in region on chromosome 15q25.1 associated with lung cancer and African Americans than in whites, with average annual age- measures of nicotine addiction. This region includes nicotinic ace- adjusted rates, 2001 to 2005, at 50.3 and 41.3 per 100,000, tylcholine receptor subunit genes CHRNA3 and CHRNA5. These respectively. With more than 85% of lung cancer risk attrib- studies were conducted in European or European American popu- utable to cigarette smoking, this racial variation in incidence lations and do not provide risk estimates for African Americans. The occurs even though African Americans smoke fewer ciga- goal of this study was to determine whether recently identified rettes per day than whites. In addition, an understanding of genetic variation in 3 SNPs (rs1051730, rs931794, rs8034191) on the influence of genetic susceptibility is not fully appreciated. chromosome http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Racial Differences in the Association Between SNPs on 15q25.1, Smoking Behavior, and Risk of Non-small Cell Lung Cancer

Journal of Thoracic Oncology , Volume 4 (10) – Oct 1, 2009

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ISSN
1556-0864
DOI
10.1097/JTO.0b013e3181b244ef
pmid
19641473
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Racial Differences in the Association Between SNPs on 15q25.1, Smoking Behavior, and Risk of Non-small Cell Lung Cancer Ann G. Schwartz, PhD,*† Michele L. Cote, PhD,*† Angela S. Wenzlaff, MPH,* Susan Land, PhD,‡§ and Christopher I. Amos, PhD ung cancer continues to be the leading cause of cancer Introduction: Three genome-wide association studies identified a Ldeath in the United States. Incidence rates are higher in region on chromosome 15q25.1 associated with lung cancer and African Americans than in whites, with average annual age- measures of nicotine addiction. This region includes nicotinic ace- adjusted rates, 2001 to 2005, at 50.3 and 41.3 per 100,000, tylcholine receptor subunit genes CHRNA3 and CHRNA5. These respectively. With more than 85% of lung cancer risk attrib- studies were conducted in European or European American popu- utable to cigarette smoking, this racial variation in incidence lations and do not provide risk estimates for African Americans. The occurs even though African Americans smoke fewer ciga- goal of this study was to determine whether recently identified rettes per day than whites. In addition, an understanding of genetic variation in 3 SNPs (rs1051730, rs931794, rs8034191) on the influence of genetic susceptibility is not fully appreciated. chromosome

Journal

Journal of Thoracic OncologyWolters Kluwer Health

Published: Oct 1, 2009

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