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Original Atricle Postoperative Radiotherapy is Associated with Better Survival in Non–Small Cell Lung Cancer with Involved N2 Lymph Nodes Results of an Analysis of the National Cancer Data Base John L. Mikell, MD,*¶ Theresa W. Gillespie, PhD,†‡¶ William A. Hall, MD,*¶ Dana C. Nickleach, MA,§¶ Yuan Liu, PhD,§¶ Joseph Lipscomb, PhD,║¶ Suresh S. Ramalingam, MD,†¶ Raj S. Rajpara, MD,*¶ Seth D. Force, MD,‡¶ Felix G. Fernandez, MD,‡¶ Taofeek K. Owonikoko, MD, PhD,†¶ Rathi N. Pillai, MD,†¶ Fadlo R. Khuri, MD,†¶ Walter J. Curran, MD,*¶ and Kristin A. Higgins, MD*¶ Key Words: Non–small-cell lung cancer, Radiotherapy, PORT, Introduction: Use of postoperative radiotherapy (PORT) in non– Adjuvant therapy. small-cell lung cancer remains controversial. Limited data indicate that PORT may benefit patients with involved N2 nodes. This study (J Thorac Oncol. 2015;10: 462–471) evaluates this hypothesis in a large retrospective cohort treated with chemotherapy and contemporary radiation techniques. Methods: The National Cancer Data Base was queried for patients he use of postoperative radiotherapy (PORT) for resected diagnosed 2004–2006 with resected non–small-cell lung cancer and Tnon–small-cell lung cancer (NSCLC) remains contro- pathologically involved N2 (pN2) nodes also treated with chemo- versial. A large meta-analysis of PORT trials demonstrated therapy. Multivariable Cox proportional hazards model was used to a survival detriment associated with PORT, although subset assess factors
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Mar 1, 2015
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