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Plasma Phosphatidylcholine/Free Cholesterol Ratio as an Indicator for Atherosclerosis

Plasma Phosphatidylcholine/Free Cholesterol Ratio as an Indicator for Atherosclerosis Plasma lipid profiles were determined in two inbred strains of mice, C57BR/cdJ and CBA/J, fed either a normal chow or an atherogenic diet for a 15-week period, starting at 10 weeks of age. On the chow diet, the C57BR/cdJ had significantly higher mean free cholesterol, esterified cholesterol, and total lipid values, and a significantly lower mean phosphatidylcholine/free cholesterol ratio than the CBA/J mice. On the atherogenic diet, the C57BR/cdJ had significantly higher mean levels for all lipid classes, except triacylglycerols, than the CBA/J mice. The mean plasma free cholesterol and esterified cholesterol levels of the C57BR/cdJ were four times greater than those of the CBA/J strain on the atherogenic diet. The mean plasma phosphatidylcholine/free cholesterol ratio of the C57BR/cdJ mice on the high cholesterol diet was 0.87 compared to 1.91 for CBA/J mice. These plasma lipid changes were associated with a marked development of atheromatous deposits in the wall of the aortic sinus of the C57BR/cdJ compared to the CBA/J animals. The phosphatidylcholine/free cholesterol ratios of the liver lipids of both strains decreased from 2.5-2.7 on the chow diet to 1.0-1.1 on the high cholesterol diet. It is suggested that a plasma phosphatidylcholine/free cholesterol ratio less than 1 represents a supersaturation of the vascular system and the vessel wall with cholesterol, which leads to a destabilization of the plasma membranes of the endothelial and smooth muscle cells, and an infiltration of the vessel wall by the plasma lipids. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Plasma Phosphatidylcholine/Free Cholesterol Ratio as an Indicator for Atherosclerosis

Arteriosclerosis , Volume 3 (4) – Jul 1, 1983

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Copyright
© 1983 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

Plasma lipid profiles were determined in two inbred strains of mice, C57BR/cdJ and CBA/J, fed either a normal chow or an atherogenic diet for a 15-week period, starting at 10 weeks of age. On the chow diet, the C57BR/cdJ had significantly higher mean free cholesterol, esterified cholesterol, and total lipid values, and a significantly lower mean phosphatidylcholine/free cholesterol ratio than the CBA/J mice. On the atherogenic diet, the C57BR/cdJ had significantly higher mean levels for all lipid classes, except triacylglycerols, than the CBA/J mice. The mean plasma free cholesterol and esterified cholesterol levels of the C57BR/cdJ were four times greater than those of the CBA/J strain on the atherogenic diet. The mean plasma phosphatidylcholine/free cholesterol ratio of the C57BR/cdJ mice on the high cholesterol diet was 0.87 compared to 1.91 for CBA/J mice. These plasma lipid changes were associated with a marked development of atheromatous deposits in the wall of the aortic sinus of the C57BR/cdJ compared to the CBA/J animals. The phosphatidylcholine/free cholesterol ratios of the liver lipids of both strains decreased from 2.5-2.7 on the chow diet to 1.0-1.1 on the high cholesterol diet. It is suggested that a plasma phosphatidylcholine/free cholesterol ratio less than 1 represents a supersaturation of the vascular system and the vessel wall with cholesterol, which leads to a destabilization of the plasma membranes of the endothelial and smooth muscle cells, and an infiltration of the vessel wall by the plasma lipids.

Journal

ArteriosclerosisWolters Kluwer Health

Published: Jul 1, 1983

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