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Nuclear Y-Box Binding Protein-1, a Predictive Marker of Prognosis, Is Correlated with Expression of HER2/ErbB2 and HER3/ErbB3 in Non-small Cell Lung Cancer

Nuclear Y-Box Binding Protein-1, a Predictive Marker of Prognosis, Is Correlated with Expression... ORIGINAL ARTICLE Nuclear Y-Box Binding Protein-1, a Predictive Marker of Prognosis, Is Correlated with Expression of HER2/ErbB2 and HER3/ErbB3 in Non-small Cell Lung Cancer Masaki Kashihara, MD,*† Koichi Azuma, MD, PhD,‡ Akihiko Kawahara, PhD,§ Yuji Basaki, PhD,* Satoshi Hattori, PhD,¶ Takashi Yanagawa, PhD,¶ Yasuhiro Terazaki, MD, PhD,‡ Shinzo Takamori, MD, PhD,‡ Kazuo Shirouzu, MD, PhD,‡ Hisamichi Aizawa, MD, PhD,‡ Kenji Nakano, MD, PhD, Masayoshi Kage, MD, PhD,§#Michihiko Kuwano, MD, PhD, and Mayumi Ono, PhD,* n  26) but not between those with high and those with low Introduction: Nuclear expression of Y-box binding protein-1 expression of EGFR, HER2, HER3, and c-Met. (YB-1) is closely associated not only with global drug resistance and Conclusion: Nuclear YB-1 expression might be essential for the expression of several growth factor receptors in various human malignant phenotype in lung cancer patients and might be an malignancies but also with overall patient survival. important biomarker for the development of therapeutic strategy Methods: The effect of YB-1 knockdown on expression of epider- against NSCLC. mal growth factor receptor (EGFR) family proteins was examined Key Words: YB-1, NSCLC, HER2, HER3. by Western blot using human lung cancer cell lines. Immunohisto- chemistry was used to evaluate the expression http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Nuclear Y-Box Binding Protein-1, a Predictive Marker of Prognosis, Is Correlated with Expression of HER2/ErbB2 and HER3/ErbB3 in Non-small Cell Lung Cancer

Ono, Mayumi
Journal of Thoracic Oncology , Volume 4 (9) – Sep 1, 2009
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References (30)

ISSN
1556-0864
DOI
10.1097/JTO.0b013e3181ae2828
pmid
19648825
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Nuclear Y-Box Binding Protein-1, a Predictive Marker of Prognosis, Is Correlated with Expression of HER2/ErbB2 and HER3/ErbB3 in Non-small Cell Lung Cancer Masaki Kashihara, MD,*† Koichi Azuma, MD, PhD,‡ Akihiko Kawahara, PhD,§ Yuji Basaki, PhD,* Satoshi Hattori, PhD,¶ Takashi Yanagawa, PhD,¶ Yasuhiro Terazaki, MD, PhD,‡ Shinzo Takamori, MD, PhD,‡ Kazuo Shirouzu, MD, PhD,‡ Hisamichi Aizawa, MD, PhD,‡ Kenji Nakano, MD, PhD, Masayoshi Kage, MD, PhD,§#Michihiko Kuwano, MD, PhD, and Mayumi Ono, PhD,* n  26) but not between those with high and those with low Introduction: Nuclear expression of Y-box binding protein-1 expression of EGFR, HER2, HER3, and c-Met. (YB-1) is closely associated not only with global drug resistance and Conclusion: Nuclear YB-1 expression might be essential for the expression of several growth factor receptors in various human malignant phenotype in lung cancer patients and might be an malignancies but also with overall patient survival. important biomarker for the development of therapeutic strategy Methods: The effect of YB-1 knockdown on expression of epider- against NSCLC. mal growth factor receptor (EGFR) family proteins was examined Key Words: YB-1, NSCLC, HER2, HER3. by Western blot using human lung cancer cell lines. Immunohisto- chemistry was used to evaluate the expression

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Sep 1, 2009

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