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Lipoprotein(a)

Lipoprotein(a) Review Lipoprotein(a) A Unique Risk Factor for Atherothrombotic Disease Joseph Loscalzo n 1963, Kare Berg immunized rabbits with human low the Lp(a) level as a predictor of the presence of coronary I density lipoprotein (LDL) and identified a genetic vari- artery disease was comparable in magnitude to the ation in the anti-LDL antibody response. He attributed this well-established risk factors of total and high density genetic variation to a unique fraction of LDL that he lipoprotein (HDL) cholesterol. Subgroup analysis showed termed lipoprotein(a) (Lp[a]), and he believed that this that Lp(a) levels were particularly powerful as predictors trait was transmitted in an autosomal dominant fashion. of the presence of angiographic coronary disease in Over the subsequent two decades, data obtained from women of all ages and in men younger than 56 years of 2 6 several groups - demonstrated that elevated serum age. Similar data were obtained in a parallel study in levels of Lp(a) correlate with an increased risk of athero- Hawaiian men of Japanese ancestry that showed the sclerotic vascular disease. The mechanism(s) by which generalizability of the atherosclerotic risk imparted by elevated levels of Lp(a) to non-occidental populations. Lp(a) confers this increased risk has eluded identi- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Lipoprotein(a)

Arteriosclerosis , Volume 10 (5) – Sep 1, 1990

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Copyright
© 1990 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

Review Lipoprotein(a) A Unique Risk Factor for Atherothrombotic Disease Joseph Loscalzo n 1963, Kare Berg immunized rabbits with human low the Lp(a) level as a predictor of the presence of coronary I density lipoprotein (LDL) and identified a genetic vari- artery disease was comparable in magnitude to the ation in the anti-LDL antibody response. He attributed this well-established risk factors of total and high density genetic variation to a unique fraction of LDL that he lipoprotein (HDL) cholesterol. Subgroup analysis showed termed lipoprotein(a) (Lp[a]), and he believed that this that Lp(a) levels were particularly powerful as predictors trait was transmitted in an autosomal dominant fashion. of the presence of angiographic coronary disease in Over the subsequent two decades, data obtained from women of all ages and in men younger than 56 years of 2 6 several groups - demonstrated that elevated serum age. Similar data were obtained in a parallel study in levels of Lp(a) correlate with an increased risk of athero- Hawaiian men of Japanese ancestry that showed the sclerotic vascular disease. The mechanism(s) by which generalizability of the atherosclerotic risk imparted by elevated levels of Lp(a) to non-occidental populations. Lp(a) confers this increased risk has eluded identi-

Journal

ArteriosclerosisWolters Kluwer Health

Published: Sep 1, 1990

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