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Editorial Is It Time To Measure Apolipoprotein B? or some time, evidence that apoproteins may pro- that is, hypertriglyceridemic patients who have an F vide information about the risk of premature coronary increased number of hepatic apo B-100 particles in disease beyond that evident in the plasma or lipoprotein plasma-appear to be at substantially greater risk for lipids has been accumulating. However, almost all of coronary disease than hypertriglyceridemic patients this has been derived from cross-sectional studies, and with normal apo B levels. Since Brown's study has therefore, appropriately, there has been reluctance to shown that hypertriglyceridemic patients who have ele- endorse the use of these measurements for routine vated apo B derive angiographic and clinical benefits clinical use. We believe the recent results of Brown et al. from pharmacologic therapy that lowers LDL particle should result in a reassessment of this view. Brown and number, surely now, the old debate on the old grounds his colleagues studied patients with documented coro- should end. nary disease and elevated apoprotein (apo) B treated The use of total apo B does not imply that all hepatic with dietary and pharmacologic regimens that were apo B particles are equally atherogenic. Even in
Arteriosclerosis – Wolters Kluwer Health
Published: Sep 1, 1990
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