Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Inheritance of Low Density Lipoprotein Subclass Patterns in Familial Combined Hyperlipidemia

Inheritance of Low Density Lipoprotein Subclass Patterns in Familial Combined Hyperlipidemia The Inheritance of low density lipoprotein (LDL) subclass patterns was Investigated In 234 members of seven large kindreds with familial combined hyperlipidemia (FCHL), a disorder characterized by elevated LDL cholesterol and/or trlglyceride and Increased coronary disease risk in families. Analysis of LDL subclasses by nondenaturlng gradient gel electrophoresls showed a predominance of large, buoyant LDL particles (pattern A) In 71% of the family members and a predominance of small, dense LDL particles (pattern B) In 29% of family members. Based on complex segregation analysis, pattern B appeared to be Inherited as an autosomal trait with either a dominant or an additive mode of Inheritance and a small, but significant, multlfactorlal inheritance component The proposed allele for pattern B was common (frequency=0.3), and reduced penetrance was observed among men under age 20 and among women under age 50. These results In these FCHL families are consistent with those from a previously reported population-based sample of families, In which pattern B showed an apparent dominant mode of Inheritance. In that study, reduced penetrance was observed for men under age 20 and for premenopausal women, but a somewhat lower allele frequency was found for pattern B (0.25). In the FCHL family members, LDL subclass pattern B was associated with significantly increased plasma levels of apolipoproteln B and trlglyceride and decreased high density lipoprotein cholesterol. In comparison with a group of controls, the FCHL family members with pattern A had similar mean trlglyceride levels, but higher mean apolipoproteln B. Thus, In families with FCHL, a predominance of small, dense LDL particles appears to be Inherited as a common, single-gene trait, which Is closely associated with the higher plasma trlglyceride levels found In these families. The Increased plasma apolipoproteln B levels found In FCHL cannot, however, be accounted for by this proposed locus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Inheritance of Low Density Lipoprotein Subclass Patterns in Familial Combined Hyperlipidemia

Loading next page...
 
/lp/wolters-kluwer-health/inheritance-of-low-density-lipoprotein-subclass-patterns-in-familial-b3DZCEubJF
Copyright
© 1990 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

The Inheritance of low density lipoprotein (LDL) subclass patterns was Investigated In 234 members of seven large kindreds with familial combined hyperlipidemia (FCHL), a disorder characterized by elevated LDL cholesterol and/or trlglyceride and Increased coronary disease risk in families. Analysis of LDL subclasses by nondenaturlng gradient gel electrophoresls showed a predominance of large, buoyant LDL particles (pattern A) In 71% of the family members and a predominance of small, dense LDL particles (pattern B) In 29% of family members. Based on complex segregation analysis, pattern B appeared to be Inherited as an autosomal trait with either a dominant or an additive mode of Inheritance and a small, but significant, multlfactorlal inheritance component The proposed allele for pattern B was common (frequency=0.3), and reduced penetrance was observed among men under age 20 and among women under age 50. These results In these FCHL families are consistent with those from a previously reported population-based sample of families, In which pattern B showed an apparent dominant mode of Inheritance. In that study, reduced penetrance was observed for men under age 20 and for premenopausal women, but a somewhat lower allele frequency was found for pattern B (0.25). In the FCHL family members, LDL subclass pattern B was associated with significantly increased plasma levels of apolipoproteln B and trlglyceride and decreased high density lipoprotein cholesterol. In comparison with a group of controls, the FCHL family members with pattern A had similar mean trlglyceride levels, but higher mean apolipoproteln B. Thus, In families with FCHL, a predominance of small, dense LDL particles appears to be Inherited as a common, single-gene trait, which Is closely associated with the higher plasma trlglyceride levels found In these families. The Increased plasma apolipoproteln B levels found In FCHL cannot, however, be accounted for by this proposed locus.

Journal

ArteriosclerosisWolters Kluwer Health

Published: Jul 1, 1990

There are no references for this article.