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ORIGINAL ARTICLE Genome-Wide Analysis of DNA Methylation and the Gene Expression Change in Lung Cancer Yong-Jae Kwon, PhD,* Seog Joo Lee, MSc,* Jae Soo Koh, MD, PhD,† Sung Han Kim, PhD,‡ Hae Won Lee, MD,§ Moon Chul Kang, MD,§ Jae Bum Bae, PhD, Young-Joon Kim, PhD, and Jong Ho Park, MD, PhD§ Key Words: Lung cancer, DNA methylation, Pyrosequencing, Introduction: The recent DNA methylation studies on cancers have Microarray. revealed the necessity of profiling an entire human genome and not (J Thorac Oncol. 2012;7: 20–33) to restrict the profiling to specific regions of the human genome. It has been suggested that genome-wide DNA methylation analysis enables us to identify the genes that are regulated by DNA methyl- he clinical, pathologic, and genomic characteristics of ation in carcinogenesis. Tlung cancer are very diverse, and the most decisive Methods: So, we performed whole-genome DNA methylation anal- treatment for it is to perform a curative resection at its earliest ysis for human lung squamous cell carcinoma (SCC), which is detection. Nevertheless, lung cancer still has been reported to strongly related with smoking. We also performed microarrays using be one of the most common malignant diseases with a poor 21 pairs of normal
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jan 1, 2012
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