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Familial Hypercholesterolemia

Familial Hypercholesterolemia Introduction 50 Years of Research he Norwegian physician Carl Muller was the first investigator to publish the results of T clinical studies alluding to the heritability of heart disease in connection with xanthomas and high blood cholesterol levels. He wrote several articles on this subject between 1936 and 1939, the most important of which was published in the Archives of Internal Medicine^ in 1939, thus establishing, as a clinical and biochemical entity, the condition that later became known as familial hypercholesterolemia. Carl Muller published his doctoral dissertation on the measurement of blood pressure in 1922. From 1927, he was Medical Director of the Eighth Department of Medicine at Oslo Community Hospital. In 1951, he was appointed Professor of Medicine at the University of Oslo. He retired in 1956 but remained active in private practice until just before his death, in 1983, at the age of 97. Xanthomatosis was the focus of his landmark article in the Archives of Internal Medicine. Previous studies had documented the significance of xanthomas, and it was surmised that they were heritable. Of particular importance to Dr. Muller were the observations by the Norwegian surgeon Francis Harbitz2 who demonstrated the connection between xantho- mas and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Familial Hypercholesterolemia

Arteriosclerosis , Volume 9 – Jan 1, 1989

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ISSN
0276-5047

Abstract

Introduction 50 Years of Research he Norwegian physician Carl Muller was the first investigator to publish the results of T clinical studies alluding to the heritability of heart disease in connection with xanthomas and high blood cholesterol levels. He wrote several articles on this subject between 1936 and 1939, the most important of which was published in the Archives of Internal Medicine^ in 1939, thus establishing, as a clinical and biochemical entity, the condition that later became known as familial hypercholesterolemia. Carl Muller published his doctoral dissertation on the measurement of blood pressure in 1922. From 1927, he was Medical Director of the Eighth Department of Medicine at Oslo Community Hospital. In 1951, he was appointed Professor of Medicine at the University of Oslo. He retired in 1956 but remained active in private practice until just before his death, in 1983, at the age of 97. Xanthomatosis was the focus of his landmark article in the Archives of Internal Medicine. Previous studies had documented the significance of xanthomas, and it was surmised that they were heritable. Of particular importance to Dr. Muller were the observations by the Norwegian surgeon Francis Harbitz2 who demonstrated the connection between xantho- mas and

Journal

ArteriosclerosisWolters Kluwer Health

Published: Jan 1, 1989

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