Access the full text.
Sign up today, get DeepDyve free for 14 days.
B Trachet, L Aslanidou, A Piersigilli, RA Fraga-Silva, J Sordet-Dessimoz, P Villanueva-Perez, MFM Stampanoni, N Stergiopulos, P Segers (2017)
Angiotensin II infusion into ApoE-/- mice: a model for aortic dissection rather than abdominal aortic aneurysm?, 113
B Trachet, RA Fraga-Silva, A Piersigilli, A Tedgui, J Sordet-Dessimoz, A Astolfo, C Van der Donckt, P Modregger, MF Stampanoni, P Segers (2015)
Dissecting abdominal aortic aneurysm in Ang II-infused mice: suprarenal branch ruptures and apparent luminal dilatation., 105
A Daugherty, MW Manning, LA Cassis (2000)
Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice., 105
SN Angelov, JH Hu, H Wei, N Airhart, M Shi, DA Dichek (2017)
TGF-β (transforming growth factor-β) signaling protects the thoracic and abdominal aorta from angiotensin II-induced pathology by distinct mechanisms., 37
D Weiss, M Latorre, BV Rego, C Cavinato, BJ Tanski, AG Berman, CJ Goergen, JD Humphrey (2021)
Biomechanical consequences of compromised elastic fiber integrity and matrix cross-linking on abdominal aortic aneurysmal enlargement., 134
MR Bersi, R Khosravi, AJ Wujciak, DG Harrison, JD Humphrey (2017)
Differential cell-matrix mechanoadaptations and inflammation drive regional propensities to aortic fibrosis, aneurysm or dissection in hypertension., 14
MB Sheppard, A Daugherty, H Lu (2016)
Insights into ascending aortic aneurysm pathogenesis using in vivo and ex vivo imaging systems in angiotensin II-infused mice., 8
EH Phillips, P Di Achille, MR Bersi, JD Humphrey, CJ Goergen (2017)
Multi-modality imaging enables detailed hemodynamic simulations in dissecting aneurysms in mice., 36
J Ferruzzi, MR Bersi, JD Humphrey (2013)
Biomechanical phenotyping of central arteries in health and disease: advantages of and methods for murine models., 41
MR Bersi, VA Acosta Santamaría, K Marback, P Di Achille, EH Phillips, CJ Goergen, JD Humphrey, S Avril (2020)
Multimodality imaging-based characterization of regional material properties in a murine model of aortic dissection., 10
C Cavinato, M Chen, D Weiss, MJ Ruiz-Rodríguez, MA Schwartz, JD Humphrey (2021)
Progressive microstructural deterioration dictates evolving biomechanical dysfunction in the marfan aorta., 8
TJ Creamer, EE Bramel, EG MacFarlane (2021)
Insights on the pathogenesis of aneurysm through the study of hereditary aortopathies., 12
H Sawada, JZ Chen, BC Wright, JJ Moorleghen, HS Lu, A Daugherty (2019)
Ultrasound imaging of the thoracic and abdominal aorta in mice to determine aneurysm dimensions., 145
ME Lindsay, HC Dietz (2014)
The genetic basis of aortic aneurysm., 4
JA Elefteriades (2008)
Thoracic aortic aneurysm: reading the enemy’s playbook., 33
SJ Mousavi, S Farzaneh, S Avril (2019)
Patient-specific predictions of aneurysm growth and remodeling in the ascending thoracic aorta using the homogenized constrained mixture model., 18
J Ferruzzi, SI Murtada, G Li, Y Jiao, S Uman, MY Ting, G Tellides, JD Humphrey (2016)
Pharmacologically improved contractility protects against aortic dissection in mice with disrupted transforming growth factor-β signaling despite compromised extracellular matrix properties., 36
A Poduri, DL Rateri, DA Howatt, A Balakrishnan, JJ Moorleghen, LA Cassis, A Daugherty (2015)
Fibroblast angiotensin II type 1a receptors contribute to angiotensin II-induced medial hyperplasia in the ascending aorta., 35
LA Pape, M Awais, EM Woznicki, T Suzuki, S Trimarchi, A Evangelista, T Myrmel, M Larsen, KM Harris, K Greason (2015)
Presentation, diagnosis, and outcomes of acute aortic dissection: 17-year trends from the international registry of acute aortic dissection., 66
B Trachet, A Piersigilli, RA Fraga-Silva, L Aslanidou, J Sordet-Dessimoz, A Astolfo, MF Stampanoni, P Segers, N Stergiopulos (2016)
Ascending aortic aneurysm in angiotensin II-infused mice: formation, progression, and the role of focal dissections., 36
E Ban, C Cavinato, JD Humphrey (2022)
Critical pressure of intramural delamination in aortic dissection., 50
JT Favreau, BT Nguyen, I Gao, P Yu, M Tao, J Schneiderman, GR Gaudette, CK Ozaki (2012)
Murine ultrasound imaging for circumferential strain analyses in the angiotensin II abdominal aortic aneurysm model., 56
C Bellini, MR Bersi, AW Caulk, J Ferruzzi, DM Milewicz, F Ramirez, DB Rifkin, G Tellides, H Yanagisawa, JD Humphrey (2017)
Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms., 14
M Latorre, JD Humphrey (2020)
Numerical knockouts-In silico assessment of factors predisposing to thoracic aortic aneurysms., 16
I El-Hamamsy, MH Yacoub (2009)
Cellular and molecular mechanisms of thoracic aortic aneurysms., 6
G Tellides (2017)
Further evidence supporting a protective role of transforming growth factor-β (TGFβ) in aortic aneurysm and dissection., 37
MR Bersi, C Bellini, J Wu, KRC Montaniel, DG Harrison, JD Humphrey (2016)
Excessive adventitial remodeling leads to early aortic maladaptation in angiotensin-induced hypertension., 67
E Ban, C Cavinato, JD Humphrey (2021)
Differential propensity of dissection along the aorta., 20
D Wu, YH Shen, L Russell, JS Coselli, SA LeMaire (2013)
Molecular mechanisms of thoracic aortic dissection., 184
JM Ruddy, JA Jones, RE Stroud, R Mukherjee, FG Spinale, JS Ikonomidis (2009)
Differential effects of mechanical and biological stimuli on matrix metalloproteinase promoter activation in the thoracic aorta., 120
C He, B Jiang, M Wang, P Ren, S Murtada, AW Caulk, G Li, L Qin, R Assi, CJ Lovoulos (2022)
mTOR inhibition prevents angiotensin II-induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice., 7
MR Bersi, C Bellini, P Di Achille, JD Humphrey, K Genovese, S Avril (2016)
Novel methodology for characterizing regional variations in material properties of murine aortas., 138
X Zhang, SE Thatcher, DL Rateri, D Bruemmer, R Charnigo, A Daugherty, LA Cassis (2012)
Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms., 110
JD Humphrey, DG Harrison, CA Figueroa, P Lacolley, S Laurent (2016)
Central artery stiffness in hypertension and aging: a problem with cause and consequence., 118
DL Rateri, JJ Moorleghen, A Balakrishnan, AP Owens, DA Howatt, V Subramanian, A Poduri, R Charnigo, LA Cassis, A Daugherty (2011)
Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice., 108
S Roccabianca, C Bellini, JD Humphrey (2014)
Computational modelling suggests good, bad and ugly roles of glycosaminoglycans in arterial wall mechanics and mechanobiology., 11
Y Wang, H Ait-Oufella, O Herbin, P Bonnin, B Ramkhelawon, S Taleb, J Huang, G Offenstadt, C Combadière, L Rénia (2010)
TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice., 120
A Daugherty, DL Rateri, IF Charo, AP Owens, DA Howatt, LA Cassis (2010)
Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice., 118
LF Hiratzka, GL Bakris, JA Beckman, RM Bersin, VF Carr, DE Casey, KA Eagle, LK Hermann, EM Isselbacher, EA Kazerooni (2010)
2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine., 121
A Pinard, GT Jones, DM Milewicz (2019)
Genetics of thoracic and abdominal aortic diseases., 124
G Koullias, R Modak, M Tranquilli, DP Korkolis, P Barash, JA Elefteriades (2005)
Mechanical deterioration underlies malignant behavior of aneurysmal human ascending aorta., 130
DCH van Dorst, NP de Wagenaar, I van der Pluijm, JW Roos-Hesselink, J Essers, AHJ Danser (2021)
Transforming growth factor-β and the renin-angiotensin system in syndromic thoracic aortic aneurysms: implications for treatment., 35
DC Iliopoulos, EP Kritharis, AT Giagini, SA Papadodima, DP Sokolis (2009)
Ascending thoracic aortic aneurysms are associated with compositional remodeling and vessel stiffening but not weakening in age-matched subjects., 137
DL Rateri, FM Davis, A Balakrishnan, DA Howatt, JJ Moorleghen, WN O’Connor, R Charnigo, LA Cassis, A Daugherty (2014)
Angiotensin II induces region-specific medial disruption during evolution of ascending aortic aneurysms., 184
JD Humphrey, MA Schwartz, G Tellides, DM Milewicz (2015)
Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections., 116
T Faggion Vinholo, AJ Brownstein, BA Ziganshin, MA Zafar, H Kuivaniemi, SC Body, AE Bale, JA Elefteriades (2019)
Genes associated with thoracic aortic aneurysm and dissection: 2019 update and clinical implications., 7
K Genovese, P Badel, C Cavinato, B Pierrat, MR Bersi, S Avril, JD Humphrey (2021)
Multi-view digital image correlation systems for in vitro testing of arteries from mice to humans., 61
D Weiss, C Cavinato, A Gray, AB Ramachandra, S Avril, JD Humphrey, M Latorre (2020)
Mechanics-driven mechanobiological mechanisms of arterial tortuosity., 6
MR Bersi, C Bellini, JD Humphrey, S Avril (2019)
Local variations in material and structural properties characterize murine thoracic aortic aneurysm mechanics., 18
S Sherifova, GA Holzapfel (2019)
Biomechanics of aortic wall failure with a focus on dissection and aneurysm: a review., 99
Background: Thoracic aortopathy associates with extracellular matrix remodeling and altered biomechanical properties. We sought to quantify the natural history of thoracic aortopathy in a common mouse model and to correlate measures of wall remodeling such as aortic dilatation or localized mural defects with evolving microstructural composition and biomechanical properties of the wall. Methods: We combined a high-resolution multimodality imaging approach (panoramic digital image correlation and optical coherence tomography) with histopathologic examinations and biaxial mechanical testing to correlate spatially, for the first time, macroscopic mural defects and medial degeneration within the ascending aorta with local changes in aortic wall composition and mechanical properties. Results: Findings revealed strong correlations between local decreases in elastic energy storage and increases in circumferential material stiffness with increasing proximal aortic diameter and especially mural defect size. Mural defects tended to exhibit a pronounced biomechanical dysfunction that is driven by an altered organization of collagen and elastic fibers. Conclusions: While aneurysmal dilatation is often observed within particular segments of the aorta, dissection and rupture initiate as highly localized mechanical failures. We show that wall composition and material properties are compromised in regions of local mural defects, which further increases the dilatation and overall structural vulnerability of the wall. Identification of therapies focused on promoting robust collagen accumulation may protect the wall from these vulnerabilities and limit the incidence of dissection and rupture.
Arteriosclerosis Thrombosis and Vascular Biology – Wolters Kluwer Health
Published: Aug 30, 2022
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.