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Effects of Saturated and Polyunsaturated Dietary Fat on the Concentrations of HDL Subpopulations in African Green Monkeys

Effects of Saturated and Polyunsaturated Dietary Fat on the Concentrations of HDL Subpopulations... The effect of the type of dietary fat on the concentrations and compositions of high density llpoproteln (HDL) subpopulations was studied In groups of African green monkeys consuming 40% of calories as fat supplied as saturated fat (P/S = 0.3) or polyunsaturated fat (P/S = 2.2) In the presence of either 0.8 mg or 0.03 mg cholesterol/kcal. Plasma HDL cholesterol concentrations were lower In polyunsaturated fat-fed animals. The distribution of mass among HDL subtractions was assessed by analytic ultracentrrfugatlon (AnUC), density gradient ultracentrlfugatlon (DGUC), and polyacrylamlde gradient gel electrophoresls (GGE). This made It possible to characterize and quantltate the HDL subpopulations HDL2b, HDL2a, HDL3a, HDL3band HDL3c(arranged In order of decreasing particle size and decreasing cholesterol content). Polyunsaturated fat-fed animals had lower concentrations of the large, cholesterol-rich subpopulatlon, as well as higher concentrations of Intermediate size HDL z. HDL3. on the high cholesterol diet; HDL3aand HDL3bon the low cholesterol diet). Consistent with the observed fat-related redistribution of HDL mass, the saturated fat-fed monkeys had higher apo A-l/apo A-ll ratios. The larger HDL often contained detectable apo E; however, the concentration of apo E In HDL was low In both saturated and polyunsaturated fat-fed animals. Thus, compared to saturated fat, dietary polyunsaturated fat Induced the formation of smaller size HDL subpopulations and, therefore, an overall lower cholesterol content per particle for plasma HDL. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Effects of Saturated and Polyunsaturated Dietary Fat on the Concentrations of HDL Subpopulations in African Green Monkeys

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Copyright
© 1988 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

The effect of the type of dietary fat on the concentrations and compositions of high density llpoproteln (HDL) subpopulations was studied In groups of African green monkeys consuming 40% of calories as fat supplied as saturated fat (P/S = 0.3) or polyunsaturated fat (P/S = 2.2) In the presence of either 0.8 mg or 0.03 mg cholesterol/kcal. Plasma HDL cholesterol concentrations were lower In polyunsaturated fat-fed animals. The distribution of mass among HDL subtractions was assessed by analytic ultracentrrfugatlon (AnUC), density gradient ultracentrlfugatlon (DGUC), and polyacrylamlde gradient gel electrophoresls (GGE). This made It possible to characterize and quantltate the HDL subpopulations HDL2b, HDL2a, HDL3a, HDL3band HDL3c(arranged In order of decreasing particle size and decreasing cholesterol content). Polyunsaturated fat-fed animals had lower concentrations of the large, cholesterol-rich subpopulatlon, as well as higher concentrations of Intermediate size HDL z. HDL3. on the high cholesterol diet; HDL3aand HDL3bon the low cholesterol diet). Consistent with the observed fat-related redistribution of HDL mass, the saturated fat-fed monkeys had higher apo A-l/apo A-ll ratios. The larger HDL often contained detectable apo E; however, the concentration of apo E In HDL was low In both saturated and polyunsaturated fat-fed animals. Thus, compared to saturated fat, dietary polyunsaturated fat Induced the formation of smaller size HDL subpopulations and, therefore, an overall lower cholesterol content per particle for plasma HDL.

Journal

Arteriosclerosis – Wolters Kluwer Health

Published: Jan 1, 1988

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