The effect of dietary magnesium (Mg) on the development of atherosclerosis In cholesterol-fed rabbits was investigated. Male New Zealand White rabbits (n=31) were placed on five kinds of diets: regular, 1% cholesterol, and cholesterol diets supplemented with either 300, 600, or 900 mg (as Mg) of Mg sulfate. The regular and 1% cholesterol diets contained 400 mg of Mg per 100 g. Each rabbit received 100 g daily of the appropriate diet Additional Mg was well tolerated and did not affect blood pressure or body weight The rabbits were sacrificed after 10 weeks, and the oil red O-posrave atherosclerotic area that covered the aortic Intima and the cholesterol content of the aorta was measured. Additional Mg decreased both the area of the aortic lesions and the cholesterol content of the aortas In a dose-dependent manner. The 1% cholesterol diet significantly Increased plasma cholesterol and triglycerlde concentrations and decreased high density llpoprotein (HDL) cholesterol concentration. Additional Mg had no further effect on cholesterol and HDL cholesterol concentrations, but it slightly decreased the rise In triglycerlde concentration. These results Indicate that dietary Mg prevents the development of atherosclerosis In cholesterol-fed rabbits by Inhibiting llpld accumulation In the aortic wall.
Arteriosclerosis – Wolters Kluwer Health
Published: Sep 1, 1990