Downloaded from https://journals.lww.com/drug-monitoring by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCywCX1AWnYQp/IlQrHD35y8U/jUqeEyVMweXB0LtB1dl03evjuXlpE8l2qkMB64= on 12/14/2019 ERRATUM Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Antipsychotics: Drawbacks of Its Clinical Application: Erratum In the June 2018 issue of Therapeutic Drug Monitoring, in the article “Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Antipsychotics: Drawbacks of Its Clinical Application” by Kloosterboer et al., the authors have noted an error in formula 2 (page 345). The correct formula should read: Plasma ¼ DBS - intercept slope : estimated concentration concentration Deming regression Deming regression Additionally, the agreement was checked with formula 3: Plasma ¼ ðDBS Þ slope : estimated concentration concentration Deming regression The revised table 2 and 3 are included below. The adjustments have no inﬂuence on the main ﬁndings nor conclusions of the article. Furthermore, the correct afﬁliations for Sanne M. Kloosterboer, MD are the Department of Hospital Pharmacy, Erasmus MC, Rotterdam, the Netherlands, and the Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, Rotterdam, the Netherlands. Table 2. Results of Deming regression analyses for the comparison of DBS and Estimated Plasma Concentrations Analyte n* Conversion formula* Slope 95% CI Intercept 95% CI Risperidone 33 1,3 EPC = (DBS/(1-ht))/1.120 0.999 0.935 to 1.062 20.339 21.468 to 0.791 9-OH risperidone 33 1,3 EPC = (DBS/(1-ht))/0.996 1.001 0.813 to 1.188 0.069 27.545 to 7.682 Aripiprazole 20 1,3 EPC = (DBS/(1-ht))/1.263 0.977 0.754 to 1.200 222.71 265.52 to 20.11 Dehydro-aripiprazole 20 1,3 EPC = (DBS/(1-ht))/1.242 0.958 0.642 to 1.273 27.291 227.58 to 12.99 Pipamperone 21 3 EPC = DBS/0.158 1.216 0.839 to 1.593 20.682 249.34 to 47.97 Ht, hematocrit; EPC, estimated plasma concentration *For formula 1, only cases with known hematocrit were used. Hematocrit missing for n=2 for risperidone, n=1 for aripiprazole Table 3. Results of Bland Altman analysis of DBS versus Estimated Plasma Concentrations 95% limits ∆ within 20% ∆ within 25% Analyte n* Mean bias of agreement of average (%) of average (%) Risperidone 33 20.349 25.889 to 5.192 48% 55% 9-OH risperidone 33 0.085 227.685 to 27.855 36% 52% Aripiprazole 20 226.308 2118.713 to 66.098 40% 45% Dehydro-aripiprazole 20 29.639 247.359 to 28.081 40% 45% Pipamperone 21 18.204 2103.599 to 140.006 33% 52% For formulas of estimated plasma concentrations, see table 2. *For risperidone, aripiprazole, and their metabolites, only cases with known hematocrit were analyzed. Hematocrit missing for n=2 for risperidone, n=1 for aripiprazole. REFERENCE Kloosterboer SM, de Winter BCM, Bahmany S, et al. Dried blood spot analysis for therapeutic drug monitoring of antipsychotics: drawbacks of its clinical application. Ther Drug Monit. 2018;40:344-350. 772 Ther Drug Monit Volume 41, Number 6, December 2019 Copyright © 2019 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. Downloaded from https://journals.lww.com/drug-monitoring by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCywCX1AWnYQp/IlQrHD35y8U/jUqeEyVMweXB0LtB1dl03evjuXlpE8l2qkMB64= on 12/14/2019
Therapeutic Drug Monitoring – Wolters Kluwer Health
Published: Dec 1, 2019
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