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ORIGINAL ARTICLE Diagnostic Performance of Low-Dose Computed Tomography Screening for Lung Cancer over Five Years Giulia Veronesi, MD,* Patrick Maisonneuve, DipEng,† Lorenzo Spaggiari, MD,*‡ Cristiano Rampinelli, MD,§ Alessandro Pardolesi, MD,* Raffaella Bertolotti, MSc,* Niccolò Filippi, MD,* and Massimo Bellomi, MD‡§ advanced cancers, and misdiagnoses, need to be reduced, perhaps by Introduction: Low-dose computed tomography (LD-CT) screen- risk modeling and use of serum markers. ing can reduce lung cancer mortality; however, it is essential to improve nodule management protocols. We analyze the perfor- Key Words: Lung cancer, Computed tomography, Screening, mance of the diagnostic protocol of the Continuous Observation of Surgery. SMOking Subjects single-center screening study, after long-term (J Thorac Oncol. 2014;9: 935–939) follow-up. Methods: Between 2004 and 2005, 5203 asymptomatic high-risk individuals (≥20 pack-years, aged 50 years or older) were enrolled arly detection is essential for successful lung cancer to undergo annual LD-CT for 5 years. Nodules 5 mm or smaller Etreatment. During the last 15 years, several studies underwent repeat LD-CT a year later. Nodules larger than 5.0 mm have shown that low-dose computed tomography (LD-CT), and 8.0 mm or smaller received LD-CT 3 to 6 months later. Nodules without contrast, can reliably diagnose lung nodules of a larger than 8.0 mm or growing underwent CT-positron emission few millimeters
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jul 1, 2014
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