Protein C and protein S are vitamin K-dependent coagulation factors that together act as an antocoagulant, and antithrombin III is a plasma protein that inhibitis sevferal activitied factors in the coagulation cascade. Although deficiencies of any of these three protein have been associated with venous thrombosis, arterial thrombosis has not been prominently associated with deficiencies of these factors. We report one patient with a protein S deficiency, another with a protein C deficiency, and a third with an antithrombin III deficiency, each of whom who had extensive arterial thrombosis. We suggest that deficiencies of these proteins may constitute risk factors for arterial thrombosis.
Arteriosclerosis – Wolters Kluwer Health
Published: Sep 1, 1987